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产品信息
PA1-30319
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide between 160-190 amino acids from human RYK.
偶联物
形式
Liquid
浓度
0.40 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2183043
产品详细信息
Detects a band of approximately 67.5 kDa (predicted molecular weight: 72 kDa).
Positive Control: Jurkat cell lysate.
Store as concentrated solution. Centrifuge briefly prior to opening vial.
靶标信息
RYK is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. A nine nucleotide insertion in some transcripts results in the SLG variant. It is not established whether this is a product of alternative splicing or a second gene, since evidence for a second gene or pseudogene on chromosome 17 exists.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: ERK3; growth factor receptor; hydroxyaryl-protein kinase; JTK5A protein tyrosine kinase; Kinase VIK; Met-related kinase; NYK-R; Tyrosine-protein kinase RYK
基因别名: AW536699; D3S3195; ERK-3; JTK5; JTK5A; Mrk; RYK; RYK1; Vik
UniProt ID: (Human) P34925, (Mouse) Q01887
Entrez Gene ID: (Human) 6259, (Rat) 140585, (Mouse) 20187
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
transmembrane signaling receptor activity
frizzled binding
protein binding
ATP binding
Wnt-protein binding
Wnt-activated receptor activity
coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway
nucleotide binding
protein kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
transmembrane signal receptor
protein phosphorylation
signal transduction
axonogenesis
axon guidance
synapse assembly
Wnt signaling pathway
peptidyl-tyrosine phosphorylation
neurogenesis
corpus callosum development
neuron differentiation
neuron projection development
cell proliferation in midbrain
non-canonical Wnt signaling pathway
chemorepulsion of dopaminergic neuron axon
positive regulation of MAPK cascade
canonical Wnt signaling pathway
commissural neuron axon guidance
planar cell polarity pathway involved in axon guidance
midbrain dopaminergic neuron differentiation
Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation
skeletal system morphogenesis
negative regulation of axon extension involved in axon guidance
negative chemotaxis
phosphorylation
