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产品信息
OSR00268W-100UL
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Not Applicable
宿主/亚型
Rabbit
/ Ig
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide from human RalA conjugated to blue carrier protein was used as the antigen
偶联物
形式
Lyophilized
浓度
Conc. Not Determined
保存液
whole serum
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
The peptide is homologous in rat and mouse.
Specificity of this antibody: Ral-A.
靶标信息
Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Plays a role in the early stages of cytokinesis and is required to tether the exocyst to the cytokinetic furrow. The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling. Key regulator of LPAR1 signaling and competes with GRK2 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: -ral simian leukemia viral oncogene homolog A (ras related); MGC48949; ral-A protein; Ras family small GTP binding protein RALA; ras related GTP binding protein A; RAS-like protein A; RAS-like, family 1; Ras-related protein Ral-A; v-ral simian leukemia viral oncogene homolog A (ras related)
基因别名: 3010001O15Rik; AW322615; RAL; Ral-a; RALA; Rasl1
UniProt ID: (Human) P11233, (Mouse) P63321, (Rat) P63322
Entrez Gene ID: (Human) 5898, (Mouse) 56044, (Rat) 81757
cytokinesis
neural tube closure
exocytosis
chemotaxis
signal transduction
Ras protein signal transduction
viral process
regulation of exocytosis
actin cytoskeleton reorganization
positive regulation of filopodium assembly
membrane raft localization
membrane organization
cell cycle
small GTPase mediated signal transduction
cell division
metabolic process
