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Invitrogen
Ras (G12D Mutant) Recombinant Rabbit Monoclonal Antibody (HL10)
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Ras (G12D Mutant) Antibody (MA5-36256) in IHC (P)
Immunohistochemistry (Paraffin) analysis performed in paraffin-embedded KPC mouse pancreatic tumor cells implanted in the pancreas of B6 mice (left) and normal mouse pancreas (right). RAS (G12D Mutant) stained by Ras (G12D Mutant) Antibody (Product # MA5-36256) diluted at 1:75. Antigen Retrieval: Citrate buffer, pH 6.0, 40 min.
产品信息
MA5-36256
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
HL10
抗原
Synthetic peptide corresponding to human RAS (G12D Mutant).
偶联物
形式
Liquid
浓度
1.5 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2890403
靶标信息
Ras is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. The process of shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in Ras gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: GTPase NRas; N-ras protein part 4; neuroblastoma RAS viral (v-ras) oncogene homolog; Transforming protein N-Ras; v-ras neuroblastoma RAS viral oncogene homolog
基因别名: ALPS4; AV095280; CMNS; HRAS1; N-ras; NCMS; NRAS; NRAS1; NS6
UniProt ID: (Human) P01111
Entrez Gene ID: (Human) 4893, (Mouse) 18176
MAPK cascade
stimulatory C-type lectin receptor signaling pathway
epidermal growth factor receptor signaling pathway
Ras protein signal transduction
axon guidance
Fc-epsilon receptor signaling pathway
ERBB2 signaling pathway
leukocyte migration
establishment of protein localization to Golgi
regulation of protein phosphorylation
signal transduction
small GTPase mediated signal transduction
regulation of gene expression
positive regulation of fibroblast proliferation
negative regulation of skeletal muscle tissue development
regulation of cell cycle
