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Rb Antibody (MA5-51348) in IHC (P)
Immunohistochemistry analysis of Rb in paraffin-embedded Mouse spleen. Samples were incubated with Rb Recombinant monoclonal antibody (Product # MA5-51348) using a dilution of 1:200 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
产品信息
MA5-51348
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
2R4M3
抗原
A synthetic peptide corresponding to a sequence within amino acids 750-850 of human RB1 (NP_000312.2).
偶联物
形式
Liquid
浓度
0.21 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_3093814
产品详细信息
Immunogen sequence: DSIIVFYNSV FMQRLKTNIL QYASTRPPTL SPIPHIPRSP YKFPSSPLRI PGGNIYISPL KSPYKISEGL PTPTKMTPRS RILVSIGESF GTSEKFQKIN Q
靶标信息
Rb is a tumor suppressor nuclear phosphoprotein capable of binding to DNA. It is phosphorylated on serine and threonine, but not on tyrosine residues. It forms a complex with SV40 large T antigen, adenovirus E1A, and human papilloma virus-16 E. Rb protein may act by regulating transcription and loss of its function leads to uncontrolled cell growth. Aberrations in the RB gene have been implicated in cancers of breast, colon, prostate, kidney, nasopharynx, and leukemia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Cleaved Rb; delta RB-p70; DRb-p70; P105RB; p110-RB1; Phospho-Retinoblastoma; pp105; pRb; Rb; Rb-p70; Retin; Retinoblastoma; Retinoblastoma 1 (including osteosarcoma); retinoblastoma gene; Retinoblastoma-associated protein
基因别名: pRb; Rb; Rb-1; Rb1
UniProt ID: (Rat) P33568, (Mouse) P13405
Entrez Gene ID: (Rat) 24708, (Mouse) 19645
core promoter binding
RNA polymerase II activating transcription factor binding
DNA binding
protein binding
transcription factor binding
enzyme binding
kinase binding
ubiquitin protein ligase binding
identical protein binding
phosphoprotein binding
chromatin/chromatin-binding, or -regulatory protein
G1/S transition of mitotic cell cycle
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
negative regulation of protein kinase activity
cell cycle arrest
Ras protein signal transduction
spermatogenesis
regulation of mitotic cell cycle
negative regulation of cell proliferation
chromatin modification
neuron differentiation
sister chromatid biorientation
neuron projection development
maintenance of mitotic sister chromatid cohesion
glial cell apoptotic process
skeletal muscle cell differentiation
neuron maturation
negative regulation of apoptotic process
enucleate erythrocyte differentiation
regulation of lipid kinase activity
myoblast differentiation
positive regulation of macrophage differentiation
negative regulation of cell cycle
positive regulation of mitotic metaphase/anaphase transition
negative regulation of smoothened signaling pathway
negative regulation of transcription, DNA-templated
negative regulation of mitotic cell cycle
positive regulation of transcription from RNA polymerase II promoter
digestive tract development
cell morphogenesis involved in neuron differentiation
negative regulation of epithelial cell proliferation
striated muscle cell differentiation
cell division
neuron apoptotic process
regulation of cell cycle
protein localization to chromosome, centromeric region
cellular response to xenobiotic stimulus
regulation of cohesin loading
negative regulation of transcription involved in G1/S transition of mitotic cell cycle
hepatocyte apoptotic process
negative regulation of G1/S transition of mitotic cell cycle
regulation of transcription, DNA-templated
cell cycle
negative regulation of hepatocyte apoptotic process
