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产品信息
MA5-51387
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
3L1H6
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human RbAp46/RBBP7 (NP_002884.1).
偶联物
形式
Liquid
浓度
0.26 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_3094164
产品详细信息
Immunogen sequence: MASKEMFEDT VEERVINEEY KIWKKNTPFL YDLVMTHALQ WPSLTVQWLP EVTKPEGKDY ALHWLVLGTH TSDEQNHLVV ARVHIPNDDA QFDASHCDSD KGEFGGFGSV TGKIECEIKI NHEGEVNRAR YMPQNPHIIA TKTPSSDVLV FDYTKHPAKP DPSGECNPDL RLRGHQKEGY GLSWNSNLSG HLLSASDDHT VCLWDINAGP KEGKIVDAKA IFTGHSAVVE
靶标信息
This protein is a ubiquitously expressed nuclear protein and belongs to a highly conserved subfamily of WD-repeat proteins. It is found among several proteins that binds directly to retinoblastoma protein, which regulates cell proliferation. The encoded protein is found in many histone deacetylase complexes, including mSin3 co-repressor complex. It is also present in protein complexes involved in chromatin assembly. This protein can interact with BRCA1 tumor-suppressor gene and may have a role in the regulation of cell proliferation and differentiation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: G1/S transition control protein-binding protein; G1/S transition control protein-binding protein RbAp46; Histone acetyltransferase type B subunit 2; Histone-binding protein RBBP7; Nucleosome-remodeling factor subunit RBAP46; RBBP-7; retinoblastoma binding protein 7; Retinoblastoma-binding protein 7; Retinoblastoma-binding protein p46; retinoblastoma-binding protein RbAp46
基因别名: AA409861; AI173248; AU019541; BB114024; mRbAp46; RBAP46; RBBP7
UniProt ID: (Human) Q16576, (Mouse) Q60973, (Rat) Q71UF4
Entrez Gene ID: (Human) 5931, (Mouse) 245688, (Rat) 83712
negative regulation of transcription from RNA polymerase II promoter
DNA replication
transcription, DNA-templated
multicellular organism development
cell proliferation
histone deacetylation
negative regulation of cell growth
CENP-A containing nucleosome assembly
negative regulation of gene expression, epigenetic
response to steroid hormone
cellular heat acclimation
regulation of signal transduction by p53 class mediator
chromatin remodeling
regulation of transcription, DNA-templated
chromatin modification
negative regulation of transcription, DNA-templated
