Invitrogen

Reelin Recombinant Rabbit Monoclonal Antibody (JA63-13)

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抗体检测数据 (3)

Reelin Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Reelin Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Reelin Antibody (MA5-32723) in IHC (P)

Immunohistochemical analysis of Reelin of paraffin-embedded Mouse brain tissue using a Reelin Monoclonal antibody (Product #MA5-32723). Counter stained with hematoxylin.

Reelin Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Reelin Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Reelin Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Product Image Gallery

Reelin Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemical analysis of Reelin of paraffin-embedded Mouse brain tissue using a Reelin Monoclonal antibody (Product #MA5-32723). Counter stained with hematoxylin.

Reelin Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemical analysis of Reelin of paraffin-embedded Human brain tissue using a Reelin Monoclonal antibody (Product #MA5-32723). Counter stained with hematoxylin.

Reelin Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemical analysis of Reelin of paraffin-embedded Human liver tissue using a Reelin Monoclonal antibody (Product #MA5-32723). Counter stained with hematoxylin.

产品信息

MA5-32723

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:1,000

-

免疫组化（石蜡） (IHC (P))

1:50-1:200

-

产品规格

种属反应

Human, Rat

宿主/亚型

Rabbit / IgG

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

JA63-13

抗原

Synthetic peptide within Human Reelin aa 3248-3297

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

TBS, pH 7.4, with 40% Glycerol, 0.05% BSA

内含物

0.05% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

AB_2810000

产品详细信息

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

靶标信息

Reelin in an extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Reelin

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基因别名: ETL7; LIS2; PRO1598; Reelen; reeler; RELN; RL

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UniProt ID: (Human) P78509, (Rat) P58751

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Entrez Gene ID: (Human) 5649, (Rat) 24718

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protein serine/threonine/tyrosine kinase activity serine-type peptidase activity metal ion binding lipoprotein particle receptor binding very-low-density lipoprotein particle receptor binding molecular_function extracellular matrix glycoprotein extracellular matrix protein

cell morphogenesis involved in differentiation neuron migration proteolysis cell adhesion axon guidance central nervous system development brain development long-term memory associative learning glial cell differentiation positive regulation of neuron projection development positive regulation of phosphatidylinositol 3-kinase signaling dendrite development peptidyl-tyrosine phosphorylation spinal cord patterning ventral spinal cord development hippocampus development cerebral cortex tangential migration layer formation in cerebral cortex positive regulation of TOR signaling positive regulation of CREB transcription factor activity reelin-mediated signaling pathway positive regulation of protein kinase activity response to pain positive regulation of peptidyl-tyrosine phosphorylation regulation of behavior modulation of synaptic transmission positive regulation of small GTPase mediated signal transduction positive regulation of synaptic transmission, glutamatergic long-term synaptic potentiation positive regulation of dendritic spine morphogenesis positive regulation of protein tyrosine kinase activity positive regulation of synapse maturation NMDA glutamate receptor clustering postsynaptic density protein 95 clustering receptor localization to synapse lateral motor column neuron migration positive regulation of long-term synaptic potentiation positive regulation of lateral motor column neuron migration regulation of N-methyl-D-aspartate selective glutamate receptor activity positive regulation of excitatory postsynaptic potential positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity midgut development memory locomotory behavior response to mechanical stimulus response to toxic substance response to hormone response to lithium ion regulation of gene expression response to organic cyclic compound cell migration response to insecticide dentate gyrus development orbitofrontal cortex development hypothalamus development cerebral cortex development forebrain development response to progesterone social behavior protein localization to synapse thyroid hormone metabolic process response to drug response to amino acid response to ethanol response to axon injury response to corticosterone response to electrical stimulus response to fatty acid cellular response to dexamethasone stimulus