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产品信息
PA5-51509
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein corresponding to Human RhoGAP4. Recombinant protein control fragment (Product #RP-91917).
偶联物
形式
Liquid
浓度
0.05 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2646537
产品详细信息
Immunogen sequence: DRQTIETEEV NKTLKATLQA LLEVVASDDG DVLDSFQTSP STESLKSTSS DPGSRQAGRR RGQQQETETF YLTKLQEYLS GRSILAKLQA KHEKLQEALQ RGDKEEQEVS WTQYT
Highest antigen sequence identity to the following orthologs: Mouse - 83%, Rat - 88%.
靶标信息
This gene encodes a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins belonging to the RAS superfamily. The protein encoded by the orthologous gene in rat is localized to the Golgi complex and can redistribute to microtubules. The rat protein stimulates the activity of some Rho GTPases in vitro. Genomic deletions of this gene and a neighboring gene have been found in patients with nephrogenic diabetes insipidus. Multiple transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: p115; RG RhoGAP4; Rho GTPase-activating protein 4; Rho-GAP hematopoietic protein C1; Rho-type GTPase-activating protein 4
基因别名: ARHGAP4; C1; KIAA0131; p115; RGC1; RHOGAP4; SrGAP4
UniProt ID: (Human) P98171
Entrez Gene ID: (Human) 393
cytoskeleton organization
Rho protein signal transduction
positive regulation of signal transduction
negative regulation of fibroblast migration
negative regulation of cell migration
negative regulation of axon extension
positive regulation of apoptotic process
positive regulation of GTPase activity
regulation of small GTPase mediated signal transduction
