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RhoH Antibody (PA5-75334) in IHC (P)
Immunohistochemistry analysis of RhoH in paraffin-embedded human rectum carcinoma tissue (cytoplasmic and cell membrane staining) and negative control (right, with PBS only). Samples were incubated with RhoH polyclonal antibody (Product # PA5-75334) at a dilution of 1:50, followed by goat Anti-Rabbit IgG-biotin and avidin peroxidase.
产品信息
PA5-75334
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to amino acids 102-152 of Human RhoH.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2719062
产品详细信息
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
靶标信息
The Rho subfamily of small GTP-binding proteins mediates many fundamental cellular functions. The commonly studied members (Rho, Rac, and CDC42) regulate actin reorganization and affect diverse cellular responses, including adhesion, cytokinesis, and motility. RhoH, also known as TTF (Translocation Three Four), Rho-related GTP-binding protein and ras homolog gene family member H, is unlike most other small G proteins. Most small G proteins are expressed ubiquitously, however, Rho H is expressed only in hemopoietic cells and tissues. Translocations and a high frequency of Rho H mutation have been detected in primary lymphoma cells. Rho H expression has also been observed in activated neutrophils. RhoH is GTPase deficient, remaining in a GTP-bound activated state without cycling. Rho H may be involved in the functional differentiation of T cells and in cytoskeleton organization. The RhoH/TTF (ARHH) gene maps to chromosome 4p13 and encodes a 191 -amino acid polypeptide.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: GTP-binding protein TTF; ras homolog gene family, member H; Rho-related GTP-binding protein RhoH; Translocation three four protein; TTF, translocation three four
基因别名: 5830400A04Rik; ARHH; AU019774; RHOH; TTF
UniProt ID: (Human) Q15669, (Mouse) Q9D3G9
Entrez Gene ID: (Human) 399, (Mouse) 74734, (Rat) 305341
regulation of transcription, DNA-templated
small GTPase mediated signal transduction
T cell differentiation
negative regulation of GTPase activity
negative regulation of phosphorylation
negative regulation of I-kappaB kinase/NF-kappaB signaling
mast cell activation
regulation of small GTPase mediated signal transduction
negative regulation of catalytic activity
