Invitrogen

RyR3 Polyclonal Antibody

RyR3 Antibody in Immunocytochemistry (ICC/IF)

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RyR3 Antibody (PA5-109321) in ICC/IF

Immunofluorescent analysis of RYR3 in Lovo cells (green). Samples were formalin fixed, permeabilized with 0.1% Triton X-100 in TBS (1 hour, room temperature) and blocked with 1% BSA (15 min, room temperature), incubated with RYR3 polyclonal antibody (Product # PA5-109321) at a dilution of 1:200 (1 hour, room temperature), and followed by Alexa Fluor 488 Goat anti-Rabbit IgG and DAPI (blue) with a dilution of 1:100.

RyR3 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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产品信息

PA5-109321

应用

建议稀释比

已发表文章

免疫组化（石蜡） (IHC (P))

1:50-1:200

免疫细胞化学 (ICC/IF)

1:100

酶联免疫吸附实验 (ELISA)

1:5,000-1:10,000

点杂交 (DB)

1:2,000-1:20,000

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein within Human RYR3 aa 1-140

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Affinity chromatography

保存液

PBS, pH 7.4, with 50% glycerol, 0.2% BSA

内含物

0.05% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles, store in dark

运输条件

Ambient (domestic); Wet ice (international)

AB_2854732

产品详细信息

Positive Control: Lovo, rat brain tissue, human kidney tissue, human placenta tissue, mouse brain tissue.

靶标信息

RYR3 is a ryanodine receptor, which functions to release calcium from intracellular storage for use in many cellular processes. RYR3 is involved in skeletal muscle contraction by releasing calcium from the sarcoplasmic reticulum followed by depolarization of T-tubules. Two transcript variants encoding different isoforms of RYR3 have been found. RYR3 mediates calcium channel release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm in muscle and plays a role in triggering muscle contraction. Further, RYR3 may also regulate Ca(2+) release by other calcium channels, as well as Ca(2+) release from the endoplasmic reticulum in non-muscle cells. RYR3 also contributes to cellular calcium ion homeostasis. Plays a role in cellular calcium signaling. Diseases associated with RYR3 include Central Core Disease and Arrhythmogenic Right Ventricular Dysplasia 2.

仅用于科研。不用于诊断过程。未经明确授权不得转售。