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Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Calvasculin; fibroblast-specific protein-1; leukemia multidrug resistance associated protein; malignant transformation suppression 1; Metastasin; Metastatic cell protein; Nerve growth factor-induced protein 42A; P9K; PEL98; Placental calcium-binding protein; pr; Protein 18A2; Protein 9 Ka homologous to calcium-binding protein; Protein Mts1; Protein S100-A4; S100 calcium-binding protein A4; S100 calcium-binding protein A4 (calcium protein, calvasculin, metastasin, murine placental homolog)
Gene Aliases: 18A2; 42A; CAPL; FSP1; metastasin; MTS1; P9KA; PEL98; pk9a; RNP9KA; S100A4
UniProt ID: (Human) P26447, (Rat) P05942, (Mouse) P07091
Entrez Gene ID: (Human) 6275, (Rat) 24615, (Mouse) 20198
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