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S100A8 Antibody (MA5-24066) in ICC/IF
Immunocytochemistry analysis of S100A8 in immersion fixed NIH-3T3 mouse embryonic fibroblast cell line. Samples were incubated in S100A8 monoclonal antibody (Product # MA5-24066) using a dilution of 10 µg/mL for 3 hours at room temperature. Cells were stained (red) and counterstained with DAPI (blue).
产品信息
MA5-24066
产品规格
种属反应
Mouse
宿主/亚型
Rat
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
335806
抗原
E. coli-derived recombinant mouse S100A8 Met1-Glu89 (predicted)
偶联物
形式
Lyophilized
浓度
0.5 mg/mL
纯化类型
Protein A/G
保存液
PBS with 5% trehalose
内含物
No Preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2609086
产品详细信息
In direct ELISAs and Western blots, 40% cross-reactivity with recombinant human (rh) S100A8 is observed and no cross-reactivity with recombinant mouse (rm) S100A4, rmS100A9, rmS100A10, rmS100A11, rhS100B, or rhS100P is observed.
Reconstitute at 0.5 mg/mL in sterile PBS.
靶标信息
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and as a cytokine. Altered expression of this protein is associated with the disease cystic fibrosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Calgranulin-A; Chemotactic cytokine CP-10; chemotactic S100 protein; Leukocyte L1 complex light chain; Migration inhibitory factor-related protein 8; MRP-8; Pro-inflammatory S100 cytokine; Protein S100-A8; S100 A8; S100 calcium-binding protein A8
基因别名: 60B8Ag; AI323541; B8Ag; Caga; CFAg; CP-10; MRP8; p8; S100a8
UniProt ID: (Mouse) P27005
Entrez Gene ID: (Mouse) 20201
immune system process
leukocyte migration involved in inflammatory response
positive regulation of peptide secretion
autophagy
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
chemotaxis
inflammatory response
peptidyl-cysteine S-nitrosylation
neutrophil chemotaxis
innate immune response
regulation of inflammatory response
positive regulation of inflammatory response
neutrophil aggregation
positive regulation of intrinsic apoptotic signaling pathway
