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产品信息
PA5-62057
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.10 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2646913
产品详细信息
Immunogen sequence: TLPSLIPFIK TEEPAPIPIS HSATSPPGSV KSDSGGPESA TRNLGGLPEE AEGSTLPPSG GKSEESGMVT NSVPT
Highest antigen sequence identity to the following orthologs: Mouse - 75%, Rat - 75%.
靶标信息
Sall1, which encodes a zinc finger protein, functions as a transcriptional repressor and interacts physically with histone deacetylase and other components of the chromatin remodeling NuRD complex. It is unknown whether the transcriptional repression is solely dependent on histone deacetylase activity. Gene expression profiling has identified Sall1 as a microglial signature gene. Microglia are the resident macrophages of the central nervous system (CNS). Sall1 is also expressed in abundance in the mesenchyme-derived structure from condensed mesenchyme, S-comma-shaped bodies, to renal tubules and podocytes. Sall1 has been identified as a key transcription factor in self-renewal renal progenitor cells. Sall1 is required to maintain the stemness of nephron progenitor cells by restraining their differentiation into renal vesicles. Defects in SALL1 are the cause of Townes-Brocks syndrome as well as bronchio-oto-renal syndrome. Heterozygous mutations of human SALL1 leading to Townes-Brocks syndrome features dysplastic ears, preaxial polydactyly, imperforate anus, and less commonly, kidney and heart anomalies (Kohlhase et al. 1998). Two transcript variants encoding different isoforms have been found for this gene.
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生物信息学
蛋白别名: epididymis secretory protein Li 89; HSal1; Sal-like protein 1; Spalt-like transcription factor 1; Zinc finger protein 794; Zinc finger protein SALL1; Zinc finger protein Spalt-1
基因别名: HEL-S-89; HSAL1; Sal-1; SAL1; SALL1; TBS; ZNF794
UniProt ID: (Human) Q9NSC2
Entrez Gene ID: (Human) 6299
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
histone deacetylase activity
protein binding
beta-catenin binding
sequence-specific DNA binding
transcription regulatory region DNA binding
metal ion binding
C2H2 zinc finger transcription factor
negative regulation of transcription from RNA polymerase II promoter
ureteric bud development
branching involved in ureteric bud morphogenesis
kidney development
ventricular septum development
mesenchymal to epithelial transition involved in metanephros morphogenesis
transcription, DNA-templated
heart development
gonad development
histone deacetylation
olfactory nerve development
olfactory bulb interneuron differentiation
pituitary gland development
neurogenesis
positive regulation of Wnt signaling pathway
adrenal gland development
inductive cell-cell signaling
somatic stem cell population maintenance
outer ear morphogenesis
embryonic digit morphogenesis
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
embryonic digestive tract development
limb development
olfactory bulb mitral cell layer development
kidney epithelium development
ureteric bud invasion
