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SAP-97/DLG1 Polyclonal Antibody

查看其他12个SAP97抗体
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说明书
实验方案
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产品信息

APZ-010-200UL

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:200
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

(C)EYRSKLSQTEDRQLR, corresponding to amino acid residues 17-31 of human SAP-97, N-terminus, L27 domain
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

0.8 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.4, with 1% BSA

内含物

0.05% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

靶标信息

This gene encodes a multi-domain scaffolding protein that is required for normal development. This protein may have a role in septate junction formation, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene, but the full-length nature of some of the variants is not known.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: discs large homolog 1; discs large homolog 1, scribble cell polarity complex component; discs, large homolog 1; discs, large homolog 1 (Drosophila) transcript variant 6-v1; discs, large homolog 1 (Drosophila) transcript variant 6-v2; Disks large homolog 1; DKFZp761P0818; DKFZp781B0426; Drosophila discs-large tumor suppressor homologue (synapse associated protein); E-dlg/SAP97; Embryo-dlg/synapse-associated protein 97; hDlg; presynaptic protein SAP97; SAP-97; Synapse-associated protein 97

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基因别名: B130052P05Rik; dJ1061C18.1.1; DLG1; DLGH1; E-dlg/SAP97; hdlg; mKIAA4187; SAP-97; SAP97

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UniProt ID: (Human) Q12959, (Rat) Q62696, (Mouse) Q62402

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Entrez Gene ID: (Human) 1739, (Rat) 25252, (Mouse) 13383

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功能
guanylate kinase activity phosphoprotein phosphatase activity protein binding protein C-terminus binding cytoskeletal protein binding ligand-gated ion channel activity potassium channel regulator activity protein kinase binding phosphatase binding mitogen-activated protein kinase kinase binding protein complex scaffold ionotropic glutamate receptor binding ion channel binding L27 domain binding cadherin binding involved in cell-cell adhesion PDZ domain binding kinase binding scaffold/adaptor protein
参与通路
negative regulation of transcription from RNA polymerase II promoter branching involved in ureteric bud morphogenesis immunological synapse formation endothelial cell proliferation lens development in camera-type eye T cell cytokine production protein dephosphorylation actin filament organization mitotic cell cycle checkpoint establishment or maintenance of cell polarity chemical synaptic transmission nervous system development positive regulation of cell proliferation regulation of cell shape viral process single organismal cell-cell adhesion peristalsis positive regulation of actin filament polymerization cortical actin cytoskeleton organization astral microtubule organization membrane raft organization regulation of myelination activation of protein kinase activity ion transmembrane transport cellular protein complex localization T cell activation negative regulation of T cell proliferation regulation of membrane potential amyloid precursor protein metabolic process receptor clustering positive regulation of potassium ion transport cortical microtubule organization establishment or maintenance of epithelial cell apical/basal polarity negative regulation of mitotic cell cycle GMP metabolic process GDP metabolic process reproductive structure development embryonic skeletal system morphogenesis smooth muscle tissue development negative regulation of epithelial cell proliferation establishment of centrosome localization negative regulation of protein kinase B signaling hard palate development negative regulation of ERK1 and ERK2 cascade bicellular tight junction assembly protein localization to plasma membrane positive regulation of establishment of protein localization to plasma membrane receptor localization to synapse regulation of NIK/NF-kappaB signaling regulation of sodium ion transmembrane transport negative regulation of p38MAPK cascade ureteric bud development cell adhesion protein localization regulation of protein localization nucleotide phosphorylation tissue morphogenesis positive regulation of multicellular organism growth positive regulation of developmental growth
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