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SAP102 Antibody (PA5-79158) in IHC (P)
Immunohistochemistry analysis of SAP102 on paraffin-embedded mouse brain tissue. Antigen retrieval was performed using citrate buffer (pH6, epitope retrieval solution) for 20 mins. Sample was blocked using 10% goat serum, incubated with SAP102 polyclonal antibody (Product# PA5-79158) with a dilution of 1 µg/mL (overnight at 4°C), and followed by biotinylated goat anti-rabbit IgG (30 minutes at 37°C). Develo... View More
产品信息
PA5-79158
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E. coli-derived human SAP102 recombinant protein (Position: E749-L817).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 5mg BSA
内含物
0.05mg sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2746274
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
靶标信息
Synapse-Associated Protein 102 (SAP102) is one of a family of plasma membrane-associated proteins found in synaptic junctions. Like other members of the family, SAP102 has three approximately 90 amino acid repeats called PDZ domains followed by an SH3 domain and a yeast guanylate kinase homology (GuK) domain. It is hypothesized that PDZ-domain interactions play a role in receptor and channel clustering which contributes to neuronal plasticity. SAP102 is believed to participate in the clustering of certain proteins, including NMDA receptors, shaker-type potassium channels at the synaptic membrane in CNS neurons. NMDA receptors and Shaker-type potassium channels both share C-terminal sequence homology consisting of a threonine/serine-X-valine-COOH (T/SXV) motif. Other neuronal proteins that share this motif (beta 1 adrenergic receptor, some serotonin receptors, some sodium channel subunits, and additional potassium channel subunits) may interact with SAP102 by binding to its PDZ domains. Neuronal nitric oxide synthase (nNOS), which lacks the T/SXV motif but which has its own PDZ domain, has been shown to associate with SAP102 in vitro through a pseudo-homotypic PDZ-PDZ interaction.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: discs large homolog 3; discs, large homolog 3; Disks large homolog 3; Neuroendocrine-DLG; protein phosphatase 1, regulatory subunit 82; PSD-95/SAP90-related protein 1; SAP-102; SAP102; Synapse-associated protein 102; XLMR
基因别名: DLG3; Dlgh3; KIAA1232; mKIAA1232; MRX; MRX90; NEDLG; PPP1R82; SAP102; XLMR
UniProt ID: (Human) Q92796, (Rat) Q62936, (Mouse) P70175
Entrez Gene ID: (Human) 1741, (Rat) 58948, (Mouse) 53310
guanylate kinase activity
protein binding
protein C-terminus binding
ligand-gated ion channel activity
kinase binding
phosphatase binding
protein phosphatase binding
PDZ domain binding
ubiquitin protein ligase binding
ionotropic glutamate receptor binding
protein domain specific binding
scaffold/adaptor protein
establishment of planar polarity
chemical synaptic transmission
nervous system development
negative regulation of cell proliferation
negative regulation of phosphatase activity
ion transmembrane transport
receptor clustering
establishment or maintenance of epithelial cell apical/basal polarity
GMP metabolic process
GDP metabolic process
receptor localization to synapse
nucleotide phosphorylation
