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产品信息
SAPC-BIOTIN
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide taken within amino acid region 460-510 on mouse Saposin-C.
偶联物
形式
Liquid
浓度
0.5-1.5 mg/mL
纯化类型
Affinity chromatography
保存液
proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Saposin C is one of four homologous proteins derived from sequential cleavage of the saposin precursor protein, prosaposin. It is an essential activator for glucocerebrosidase, the enzyme deficient in Gaucher disease. Gaucher disease is a rare autosomal recessive lysosomal storage disorder caused by mutations in the GBA gene that exhibits vast phenotypic heterogeneity, despite its designation as a simple Mendelian disorder. The observed phenotypic variability has led to a search for disease modifiers that can alter the Gaucher phenotype. The PSAP gene encoding saposin C is a prime candidate modifier for Gaucher disease.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Prosaposin; prosaposin (sulfated glycoprotein, sphingolipid hydrolase activator); Psap; SGP-1; snoRNA MBII-198; Sulfated glycoprotein 1; Uncharacterized protein
基因别名: AI037048; Psap; SGP-1; Sgp1; SGP1A
UniProt ID: (Rat) P10960, (Mouse) Q61207
Entrez Gene ID: (Rat) 25524, (Mouse) 19156
sphingolipid metabolic process
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
regulation of lipid metabolic process
regulation of MAPK cascade
positive regulation of MAPK cascade
glycolipid transport
developmental growth
prostate gland growth
epithelial cell differentiation involved in prostate gland development
cellular response to organic substance
negative regulation of hydrogen peroxide-induced cell death
lipid metabolic process
