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SART3 Antibody (PA5-103326) in ICC/IF
Immunocytochemistry analysis of SART3 in A549 cells. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with SART3 polyclonal antibody (Product # PA5-103326) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit IgG(H+L) (Red) and an AlexaFluor488 conjugated goat anti-mouse IgG(H+L) (Green) were used as the secondary antibodies. The nuclear counter stain is DAPI (blue).
产品信息
PA5-103326
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human SART3(Accession Q15020), corresponding to amino acid residues E931-K963.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2852671
产品详细信息
Antibody detects endogenous levels of total SART3.
靶标信息
The protein encoded by this gene is an RNA-binding nuclear protein that is a tumor-rejection antigen. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy. This gene product is found to be an important cellular factor for HIV-1 gene expression and viral replication. It also associates transiently with U6 and U4/U6 snRNPs during the recycling phase of the spliceosome cycle. This encoded protein is thought to be involved in the regulation of mRNA splicing.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: HIV-1 Tat-interacting protein of 110kDa; hSART-3; MGC138188; mSART-3; p110 nuclear RNA-binding protein; SART-3; squamous cell carcinoma antigen recognized by T cells 3; Squamous cell carcinoma antigen recognized by T-cells 3; Tat-interacting protein of 110 kDa; Tip110; Tumor-rejection antigen SART3
基因别名: AU045857; DSAP1; KIAA0156; mKIAA0156; P100; p110; p110(nrb); RP11-13G14; SART3; TIP110
UniProt ID: (Human) Q15020, (Mouse) Q9JLI8
Entrez Gene ID: (Human) 9733, (Mouse) 53890
spliceosomal tri-snRNP complex assembly
spliceosomal complex assembly
spliceosomal snRNP assembly
mRNA splicing, via spliceosome
cell morphogenesis
nucleosome assembly
regulation of gene expression
homeostasis of number of cells
hematopoietic stem cell proliferation
positive regulation of histone deubiquitination
RNA processing
mRNA processing
RNA splicing
