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SART3 Antibody (PA5-88362) in IHC (P)
Immunohistochemistry analysis of SART3 in paraffin-embedded human colon carcinoma. Samples were incubated with SART3 Polyclonal antibody (Product # PA5-88362) using a dilution of 1:100 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
产品信息
PA5-88362
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 664-963 of human SART3 (NP_0555211)
偶联物
形式
Liquid
浓度
0.42 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2804858
产品详细信息
Immunogen sequence: AGPAGKCAAV DVEPPSKQKE KAASLKRDMP KVLHDSSKDS ITVFVSNLPY SMQEPDTKLR PLFEACGEVV QIRPIFSNRG DFRGYCYVEF KEEKSALQAL EMDRKSVEGR PMFVSPCVDK SKNPDFKVFR YSTSLEKHKL FISGLPFSCT KEELEEICKA HGTVKDLRLV TNRAGKPKGL AYVEYENESQ ASQAVMKMDG MTIKENIIKV AISNPPQRKV PEKPETRKAP GGPMLLPQTY GARGKGRTQL SLLPRALQRP SAAAPQAENG PAAAPAVAAP AATEAPKMSN ADFAKLFLRK; Positive Samples: U-87MG, A-431, HeLa, HepG2, Jurkat; Cellular Location: Cajal body, Cytoplasm, Nucleus, Nucleus speckle, nucleoplasm
靶标信息
The protein encoded by this gene is an RNA-binding nuclear protein that is a tumor-rejection antigen. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy. This gene product is found to be an important cellular factor for HIV-1 gene expression and viral replication. It also associates transiently with U6 and U4/U6 snRNPs during the recycling phase of the spliceosome cycle. This encoded protein is thought to be involved in the regulation of mRNA splicing.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: HIV-1 Tat-interacting protein of 110kDa; hSART-3; MGC138188; mSART-3; p110 nuclear RNA-binding protein; SART-3; squamous cell carcinoma antigen recognized by T cells 3; Squamous cell carcinoma antigen recognized by T-cells 3; Tat-interacting protein of 110 kDa; Tip110; Tumor-rejection antigen SART3
基因别名: AU045857; DSAP1; KIAA0156; mKIAA0156; P100; p110; p110(nrb); RP11-13G14; SART3; TIP110
UniProt ID: (Human) Q15020, (Mouse) Q9JLI8
Entrez Gene ID: (Human) 9733, (Mouse) 53890, (Rat) 304582
spliceosomal tri-snRNP complex assembly
spliceosomal complex assembly
spliceosomal snRNP assembly
mRNA splicing, via spliceosome
cell morphogenesis
nucleosome assembly
regulation of gene expression
homeostasis of number of cells
hematopoietic stem cell proliferation
positive regulation of histone deubiquitination
RNA processing
mRNA processing
RNA splicing
