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产品信息
PA5-110349
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 585-854 of human SECISBP2 (NP_076982.3).
偶联物
形式
Liquid
浓度
0.92 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2855760
产品详细信息
Immunogen sequence: DELISTPSVE DKSEEPPGTE LQRDTEASHL APNHTTFPKI HSRRFRDYCS QMLSKEVDAC VTDLLKELVR FQDRMYQKDP VKAKTKRRLV LGLREVLKHL KLKKLKCVII SPNCEKIQSK GGLDDTLHTI IDYACEQNIP FVFALNRKAL GRSLNKAVPV SVVGIFSYDG AQDQFHKMVE LTVAARQAYK TMLENVQQEL VGEPRPQAPP SLPTQGPSCP AEDGPPALKE KEEPHYIEIW KKHLEAYSGC TLELEESLEA STSQMMNLNL
靶标信息
Eukaryotes require a selenocysteine (Sec) insertion sequence (SECIS) element in the 3' untranslated region of the mRNA to decode the UGA codon as Sec. SECIS-binding protein 2 (SBP-2) specifically binds selenoprotein mRNAs to form a functional complex and is essential for the insertion of Sec into selenoproteins. Purified SBP-2 interacts specifically with the SECIS element in the phospholipid hydroperoxide glutathione peroxidase mRNA. SBP-2 shows binding activity in the liver and testis as well as hepatoma cells. SBP-2 binds to a conserved RNA binding domain shared with several ribosomal proteins and eukaryotic translation termination release factor 1. A second domain located N-terminal to the RNA binding domain required for Sec insertion allows SBP-2 to stably associate with the ribosomal fraction of cells. SBP-2 preferentially stimulates incorporation directed by the selenoprotein P and phospholipid hydroperoxide glutathione peroxidase SECIS elements. SBP-2 may have a distinct function in selecting the ribosomes for Sec insertion.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DKFZp686C09169; OTTHUMP00000064929; OTTHUMP00000064930; OTTHUMP00000064931; OTTHUMP00000064932; RP11-89K14.1; SECIS-binding protein 2; Selenocysteine insertion sequence-binding protein 2
基因别名: 2210413N07Rik; 2810012K13Rik; SBP2; SECISBP2
UniProt ID: (Human) Q96T21, (Mouse) Q3U1C4, (Rat) Q9QX72
Entrez Gene ID: (Human) 79048, (Mouse) 75420, (Rat) 79049
