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SCAP Antibody (PA5-115869) in ICC/IF
Immunocytochemistry analysis of SCAP in HeLa cells. Samples were treated with PFA, permeabilized in 0.1% Triton X-100, blocked in 10% serum (45 min at 25°C), and incubated with polyclonal antibody (Product # PA5-115869) at a dilution of 1:200 (1 hr at 37°C). Secondary staining was applied with mouse anti-beta tubulin; AlexaFluor 594 conjugated goat anti-rabbit IgG (Red); AlexaFluor 88 conjugated goat anti-mouse IgG (Green) and DAPI (blue) using a dilution of 1:200 (1 hr at 37°C).
产品信息
PA5-115869
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human SCAP(Accession Q12770), corresponding to amino acid residues K646-G696.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2900503
产品详细信息
Antibody detects endogenous levels of total SCAP.
靶标信息
The protein encoded by this gene interacts with thyroid hormone receptor in a ligand-dependent manner and enhances thyroid hormone-dependent activation from thyroid response elements. This protein contains a bromodomain and is thought to be a nuclear receptor coactivator. Three alternatively spliced transcript variants that encode distinct isoforms have been identified.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: SCAP; scap {ECO:0000312|EMBL:AAI31853.1}; Sreb cleavage-activating protein; SREBP cleavage activating protein; SREBP cleavage-activating protein; sterol regulatory element binding protein cleavage-activating protein; Sterol regulatory element-binding protein cleavage-activating protein
基因别名: 9530044G19; KIAA0199; mKIAA0199; PSEC0227; SCAP
UniProt ID: (Human) Q12770, (Mouse) Q6GQT6, (Rat) A2RRU4
Entrez Gene ID: (Human) 22937, (Mouse) 235623, (Rat) 301024
response to hypoxia
lipid metabolic process
steroid metabolic process
cholesterol metabolic process
regulation of fatty acid metabolic process
response to insulin
SREBP signaling pathway
regulation of fatty acid biosynthetic process
regulation of cholesterol biosynthetic process
aging
negative regulation of cholesterol biosynthetic process
positive regulation of low-density lipoprotein particle receptor biosynthetic process
