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SCN1B Antibody (PA5-24142) in IHC (P)
Immunohistochemistry analysis of SCN1B in formalin fixed and paraffin embedded human brain tissue. Samples were incubated with SCN1B polyclonal antibody (Product # PA5-24142) followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of this antibody for immunohistochemistry. Clinical relevance has not been evaluated.
产品信息
PA5-24142
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide between 63-90 amino acids from the N-terminal region of human SCN1B
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A, Antigen affinity chromatography
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2541642
产品详细信息
This antibody is predicted to react with bovine, rat and rabbit based on sequence homology.
靶标信息
Voltage-gated sodium channels are heteromeric proteins that function in the generation and propagation of action potentials in muscle and neuronal cells. They are composed of one alpha and two beta subunits, where the alpha subunit provides channel activity and the beta-1 subunit modulates the kinetics of channel inactivation. SCN1B encodes a sodium channel beta-1 subunit. Mutations in this gene result in generalized epilepsy with febrile seizures plus, Brugada syndrome 5, and defects in cardiac conduction. Multiple transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Sodium channel subunit beta-1; sodium channel, voltage gated, type I beta subunit; sodium channel, voltage-gated, type I, beta; sodium channel, voltage-gated, type I, beta polypeptide
基因别名: ATFB13; BRGDA5; GEFSP1; SCN1B
UniProt ID: (Human) Q07699, (Mouse) P97952
Entrez Gene ID: (Human) 6324, (Mouse) 20266
voltage-gated sodium channel activity
protein binding
sodium channel regulator activity
sodium channel inhibitor activity
voltage-gated sodium channel activity involved in cardiac muscle cell action potential
voltage-gated sodium channel activity involved in Purkinje myocyte action potential
voltage-gated ion channel activity
sodium channel activity
regulation of sodium ion transport
transport
ion transport
sodium ion transport
axon guidance
positive regulation of sodium ion transport
positive regulation of neuron projection development
neuronal action potential propagation
corticospinal neuron axon guidance
regulation of ion transmembrane transport
sodium ion transmembrane transport
locomotion
response to pyrethroid
membrane depolarization
cardiac muscle contraction
regulation of ventricular cardiac muscle cell membrane repolarization
regulation of atrial cardiac muscle cell membrane depolarization
cardiac conduction
cardiac muscle cell action potential involved in contraction
membrane depolarization during cardiac muscle cell action potential
membrane depolarization during Purkinje myocyte cell action potential
regulation of heart rate by cardiac conduction
regulation of sodium ion transmembrane transporter activity
cell adhesion
chemical synaptic transmission
regulation of postsynaptic membrane potential
