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产品信息
PA5-36545
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to amino acids 1002-1052 of human Na+ CP type II alpha
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2553580
产品详细信息
Purity is >95% by SDS-PAGE.
靶标信息
Voltage-gated sodium channels are selective ion channels that regulate the permeability of sodium ions in excitable cells. During the propagation of an action potential, sodium channels allow an influx of sodium ions, which rapidly depolarize the cell. The alpha subunits of sodium channels type I and III are predominantly expressed in neuronal cell bodies and proximal processes, while type II alpha subunits are more abundant along axons. The beta1 subunit of sodium channel type I is expressed in brain, skeletal and cardiac muscle. In the brain, beta1 and beta2 are highly expressed in Purkinje cells, and beta1 is also expressed in the pyramidal cells of the deep cerebellar nuclei. Impaired voltage-gated sodium channels lead to a number of diseases including myotonia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: alternative product; Brain Type II; HBSC II; RIIA sodium channel protein; Sodium channel protein brain II subunit alpha; Sodium channel protein type 2 subunit alpha; Sodium channel protein type II subunit alpha; sodium channel protein, brain II subunit alpha; sodium channel protein, brain type 2 alpha subunit; sodium channel voltage-gated type II alpha polypeptide; sodium channel, voltage gated, type II alpha subunit; sodium channel, voltage-gated, type 2, alpha 1 polypeptide; sodium channel, voltage-gated, type 2, alpha 1 subunit; sodium channel, voltage-gated, type II, alpha 1; sodium channel, voltage-gated, type II, alpha 1 polypeptide; sodium channel, voltage-gated, type II, alpha 2 polypeptide; sodium channel, voltage-gated, type II, alpha polypeptide 1; sodium channel, voltage-gated, type II, alpha subunit; voltage-gated sodium channel subtype II; Voltage-gated sodium channel subunit alpha Nav1.2; voltage-gated sodium channel type II alpha subunit
基因别名: 6430408L10; A230052E19Rik; BFIC3; BFIS3; BFNIS; EIEE11; HBA; HBSCI; HBSCII; Na(v)1.2; NAC2; NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN; SCN2A; SCN2A1; SCN2A2; ScpII
UniProt ID: (Human) Q99250, (Rat) P04775, (Mouse) B1AWN6
Entrez Gene ID: (Human) 6326, (Rat) 24766, (Mouse) 110876
sodium ion transport
intrinsic apoptotic signaling pathway in response to osmotic stress
neuronal action potential
regulation of ion transmembrane transport
sodium ion transmembrane transport
myelination
neuron apoptotic process
regulation of postsynaptic membrane potential
membrane depolarization during action potential
nervous system development
