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SCN3B Antibody (MA5-45737) in ICC/IF
Immunocytochemistry/Immunofluorescence analysis using human neuroblastoma cells. Fixation involved 4% Formaldehyde for 15 min at RT. Samples were incubated with Nav beta 3 monoclonal antibody (Product # MA5-45737) at 1:100 for 60 min at RT, followed by Goat Anti-Mouse ATTO 488 at 1:100 for 60 min at RT. Counterstain used was Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1,000, 1:5,000 for 60 min RT, 5 min RT. Localization: Cell Membrane, Nucleus. Magnification: 60X. (A) DAPI (blue) nuclear stain. (B) Phalloidin Texas R... View More
产品信息
MA5-45737
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
N396/29
抗原
Fusion protein amino acids 1-215 (full-length) of rat NavBeta3
偶联物
激发/发射光谱
651/660 nm
查看光谱
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein G
保存液
95.64mM phosphate/2.48mM MES, pH 7.4, with 0.5M EDTA
内含物
no preservative
保存条件
4° C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2932191
产品详细信息
A 1:100 dilution of MA5-45737 was sufficient for detection of NavBeta3 in 20 µg of mouse brain lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. |Detects approximately 40kDa. Does not cross-reat with NavBeta1, Navbeta2, or Navbeta4.
This antibody was formerly sold as clone S396-29.
靶标信息
Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel beta subunit gene family, and influences the inactivation kinetics of the sodium channel. Two alternatively spliced variants, encoding the same protein, have been identified.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: brain and heart sodium channel beta 3 subunit; sodium channel beta 3 subunit; Sodium channel regulatory subunit beta-3; sodium channel subunit beta-3; sodium channel, voltage gated, type III beta subunit; sodium channel, voltage-gated, type III, beta subunit; voltage-gated sodium channel beta-3 subunit
基因别名: 1110001K16Rik; 4833414B02Rik; ATFB16; BRGDA7; HSA243396; KIAA1158; SCN3B; SCNB3
UniProt ID: (Human) Q9NY72, (Mouse) Q8BHK2, (Rat) Q9JK00
Entrez Gene ID: (Human) 55800, (Mouse) 235281, (Rat) 245956
voltage-gated sodium channel activity
sodium channel regulator activity
ion channel binding
voltage-gated sodium channel activity involved in cardiac muscle cell action potential
voltage-gated ion channel activity
sodium channel activity
molecular_function
ion channel
transporter
voltage-gated ion channel
sodium ion transport
nervous system development
positive regulation of heart rate
positive regulation of sodium ion transport
sensory perception of pain
sodium ion transmembrane transport
membrane depolarization
cardiac muscle contraction
regulation of postsynaptic membrane potential
regulation of atrial cardiac muscle cell membrane depolarization
regulation of ventricular cardiac muscle cell membrane depolarization
protein localization to plasma membrane
cardiac muscle cell action potential involved in contraction
ventricular cardiac muscle cell action potential
membrane depolarization during action potential
membrane depolarization during cardiac muscle cell action potential
atrial cardiac muscle cell action potential
SA node cell action potential
regulation of heart rate by cardiac conduction
regulation of sodium ion transmembrane transporter activity
transport
ion transport
regulation of ion transmembrane transport
cardiac conduction
SA node cell to atrial cardiac muscle cell communication
