Invitrogen

SCN4B Polyclonal Antibody

SCN4B Antibody in Immunocytochemistry (ICC/IF)

图: 1 / 3

SCN4B Antibody (PA5-101890) in ICC/IF

Immunofluorescent analysis of SCN4B in HeLa cells. Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and SCN4B polyclonal antibody (Product # PA5-101890) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 (red) and goat anti-mouse IgG Alexa Fluor 488 (green).

SCN4B Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Product Image Gallery

产品信息

PA5-101890

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:1,000

免疫组化（石蜡） (IHC (P))

1:50-1:200

免疫细胞化学 (ICC/IF)

1:100-1:500

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthesized peptide derived from human SCN4B(Accession Q8IWT1), corresponding to amino acid residues K184-V228.

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Affinity chromatography

保存液

PBS, pH 7.4, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice

AB_2851322

产品详细信息

Antibody detects endogenous levels of total SCN4B.

靶标信息

The SCN4B protein modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. The protein has been found to be expressed at a high level in dorsal root ganglia, at a lower level in brain, spinal cord, skeletal muscle and heart. Defects in SCN4B are the cause of long QT syndrome type 10 (LQT10) [MIM:611819]. Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress. They can present with a sentinel event of sudden cardiac death in infancy.

仅用于科研。不用于诊断过程。未经明确授权不得转售。