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产品信息
PA5-110347
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 100-250 of human SCNN1G (NP_001030.2).
偶联物
形式
Liquid
浓度
1.09 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2855758
产品详细信息
Immunogen sequence: CNINPYKYST VRHLLADLEQ ETREALKSLY GFPESRKRRE AESWNSVSEG KQPRFSHRIP LLIFDQDEKG KARDFFTGRK RKVGGSIIHK ASNVMHIESK QVVGFQLCSN DTSDCATYTF SSGINAIQEW YKLHYMNIMA QVPLEKKINM S
靶标信息
Epithelial sodium channels are amiloride-sensitive members of the degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels. Members of this superfamily of ion channels share organizational similarity in that they all possess two short intracellular amino and carboxyl termini, two short membrane spanning segments, and a large extracellular loop with a conserved cysteine-rich region. There are three homologous isoforms of the ENaC (alpha, beta, and gamma) protein. ENaC in the kidney, lung, and colon plays an essential role in trans-epithelial sodium and fluid balance. ENaC also mediates aldosterone-dependent sodium reabsorption in the distal nephron of the kidney, thus regulating blood pressure. ENaC is thought to be regulated, in part, through association with the cystic fibrosis transmembrane conductance regulator (CFTR) chloride ion channel. Gain-of-function mutations in beta- or gamma-ENaC can cause severe arterial hypertension (Liddel's syndrome) and loss-of-function mutations in alpha- or beta-ENaC causes pseudohypoaldosteronism (PHA-1).
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: amiloride sensitive sodium channel gamma1 subunit; amiloride-sensitive epithelial sodium channel gamma subunit; amiloride-sensitive sodium channel gamma-subunit; Amiloride-sensitive sodium channel subunit gamma; ENaC gamma; ENaC gamma subunit; ENaCG; Epithelial Na(+) channel subunit gamma; epithelial sodium channel gamma subunit; Gamma ENaC; Gamma NaCH; Gamma-ENaC; Gamma-NaCH; Nonvoltage-gated sodium channel 1 subunit gamma; PHA 1; SCNEG; SCNN 1G; sodium channe epithelial 1 gamma subunit; Sodium channel nonvoltage-gated 1 gamma (epithelial); sodium channel, non voltage gated 1 gamma subunit; sodium channel, non-voltage-gated 1, gamma subunit; sodium channel, nonvoltage-gated 1, gamma; Sodium channel, nonvoltage-gated 1, gamma (epithelial); sodium channel, nonvoltage-gated, type I, gamma
基因别名: [g]ENaC; BESC3; ENaC; ENaCg; ENaCgamma; PHA1; SCNEG; SCNN1G
UniProt ID: (Human) P51170, (Mouse) Q9WU39, (Rat) P37091
Entrez Gene ID: (Human) 6340, (Mouse) 20278, (Rat) 24768
