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SCP2 Antibody (PA5-92436) in IHC (P)
Immunohistochemistry analysis of SCP2 in paraffin-embedded human liver cancer. Samples were incubated with SCP2 Polyclonal antibody (Product # PA5-92436) using a dilution of 1:200 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
产品信息
PA5-92436
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-322 of human SCP2 (NP_0010070991)
偶联物
形式
Liquid
浓度
0.28 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2806499
产品详细信息
Immunogen sequence: MSSSPWEPAT LRRVFVVGVG MTKFVKPGAE NSRDYPDLAE EAGKKALADA QIPYSAVDQA CVGYVFGVAE CVLALGFEKM SKGSLGIKFS DRTIPTDKHV DLLINKYGLS AHPVAPQMFG YAGKEHMEKY GTKIEHFAKI GWKNHKHSVN NPYSQFQDEY SLDEVMASKE VFDFLTILQC CPTSDGAAAA ILASEAFVQK YGLQSKAVEI LAQEMMTDLP SSFEEKSIIK MVGFDMSKEA ARKCYEKSGL TPNDIDVIEL HDCFSTNELL TYEALGLCPE GQGATLVDRG DNTYGGKWVI NPSGGLISKG HPLGATGGHS CS; Positive Samples: Mouse liver; Cellular Location: Cytoplasm, Mitochondrion, Mitochondrion, Peroxisome
靶标信息
This gene encodes two proteins: sterol carrier protein X (SCPx) and sterol carrier protein 2 (SCP2), as a result of transcription initiation from 2 independently regulated promoters. The transcript initiated from the proximal promoter encodes the longer SCPx protein, and the transcript initiated from the distal promoter encodes the shorter SCP2 protein, with the 2 proteins sharing a common C-terminus. Evidence suggests that the SCPx protein is a peroxisome-associated thiolase that is involved in the oxidation of branched chain fatty acids, while the SCP2 protein is thought to be an intracellular lipid transfer protein. This gene is highly expressed in organs involved in lipid metabolism, and may play a role in Zellweger syndrome, in which cells are deficient in peroxisomes and have impaired bile acid synthesis. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Acetyl-CoA C-myristoyltransferase; Non-specific lipid-transfer protein; nonspecific lipid transfer protein; NSL-TP; Propanoyl-CoA C-acyltransferase; SCP-2; SCP-2/3-oxoacyl-CoA thiolase; SCP-2/thiolase; SCP-chi; SCP-X; SCPX; Sterol carrier protein 2; Sterol carrier protein X
基因别名: AA409774; AA409893; C76618; C79031; NLTP; ns-LTP; NSL-TP; SCP-2; SCP-CHI; SCP-X; SCP2; SCPX
UniProt ID: (Human) P22307, (Mouse) P32020
Entrez Gene ID: (Human) 6342, (Mouse) 20280
fatty-acyl-CoA binding
receptor binding
protein binding
sterol transporter activity
cholesterol binding
propanoyl-CoA C-acyltransferase activity
long-chain fatty acyl-CoA binding
propionyl-CoA C2-trimethyltridecanoyltransferase activity
oleic acid binding
catalytic activity
acetyl-CoA C-acyltransferase activity
lipid binding
phosphatidylcholine transporter activity
phosphatidylinositol transporter activity
transferase activity
transferase activity, transferring acyl groups
transferase activity, transferring acyl groups other than amino-acyl groups
cholesterol transporter activity
protein homodimerization activity
protein heterodimerization activity
phosphatidylethanolamine transporter activity
acyltransferase
transfer/carrier protein
bile acid biosynthetic process
peroxisome organization
sterol transport
positive regulation of intracellular cholesterol transport
fatty acid beta-oxidation using acyl-CoA oxidase
alpha-linolenic acid metabolic process
lipid hydroperoxide transport
acyl-CoA metabolic process
steroid biosynthetic process
progesterone biosynthetic process
transport
lipid transport
aging
metabolic process
positive regulation of steroid biosynthetic process
phospholipid transport
cholesterol transport
inositol trisphosphate biosynthetic process
positive regulation of apoptotic process
positive regulation of cholesterol biosynthetic process
positive regulation of steroid metabolic process
protein localization to plasma membrane
positive regulation of cholesterol import
