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产品信息
PA5-43131
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide directed towards the middle region of human SELS
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS with 2% sucrose
内含物
0.09% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2605784
产品详细信息
Peptide sequence: PDVVVKRQEA LAAARLKMQE ELNAQVEKHK EKLKQLEEEK RRQKIEMWDS
Sequence homology: Cow: 93%; Dog: 86%; Goat: 75%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 93%; Rabbit: 92%; Rat: 93%; Yeast: 90%; Zebrafish: 100%
靶标信息
This gene encodes a transmembrane protein that is localized in the endoplasmic reticulum (ER). It is involved in the degradation process of misfolded proteins in the ER, and may also have a role in inflammation control. It participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: MGC104346; MGC2553; Selenoprotein S; SelS; valosin-containing protein-interacting membrane protein; VCP-interacting membrane protein; VCP-interacting membrane selenoprotein
基因别名: AD-015; ADO15; SBBI8; SELENOS; SELS; SEPS1; VIMP
UniProt ID: (Human) Q9BQE4
Entrez Gene ID: (Human) 55829
negative regulation of acute inflammatory response to antigenic stimulus
regulation of gluconeogenesis
ER overload response
response to glucose
ER-associated ubiquitin-dependent protein catabolic process
endoplasmic reticulum unfolded protein response
retrograde protein transport, ER to cytosol
negative regulation of interleukin-6 production
negative regulation of tumor necrosis factor production
cellular response to insulin stimulus
cellular response to oxidative stress
establishment of protein localization
cell redox homeostasis
negative regulation of glycogen biosynthetic process
negative regulation of glucose import
negative regulation of inflammatory response
negative regulation of nitric-oxide synthase biosynthetic process
response to redox state
cellular response to lipopolysaccharide
regulation of nitric oxide metabolic process
cellular oxidant detoxification
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
negative regulation of macrophage apoptotic process
