Invitrogen

SEPN1 Polyclonal Antibody

SEPN1 Antibody in Immunocytochemistry (ICC/IF)

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SEPN1 Antibody (PA5-63520) in ICC/IF

Immunofluorecent analysis of SEPN1 in human cell line A-431 using SEPN1 Polyclonal Antibody (Product # PA5-63520). Staining shows localization to cytosol.

SEPN1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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产品信息

PA5-63520

应用

建议稀释比

已发表文章

免疫组化（石蜡） (IHC (P))

1:500-1:1,000

免疫细胞化学 (ICC/IF)

0.25-2 µg/mL

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein corresponding to Human SEPN1. Recombinant protein control fragment (Product #RP-99821).

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.4 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.2, with 40% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

AB_2647121

产品详细信息

Immunogen sequence: WSLVKELEEL QNKQENSSHQ KLAGLHLEKY SFPVEMMICL PNGTVVHHIN ANYFLDITSV KPEEIESNLF SFSSTFEDPS T

Highest antigen sequence identity to the following orthologs: Mouse - 83%, Rat - 80%.

靶标信息

SEPN1 is a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. Mutations in SEPN1 gene cause the classical phenotype of multiminicore disease and congenital muscular dystrophy with spinal rigidity and restrictive respiratory syndrome. This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Mutations in this gene cause the classical phenotype of multiminicore disease and congenital muscular dystrophy with spinal rigidity and restrictive respiratory syndrome. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

仅用于科研。不用于诊断过程。未经明确授权不得转售。