Invitrogen

SERPINB3 Polyclonal Antibody

SERPINB3 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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SERPINB3 Antibody (PA5-30164) in IHC (P)

Immunohistochemistry (Paraffin) analysis of SERPINB3 was performed in paraffin-embedded human cervical carcinoma tissue using SERPINB3 Polyclonal Antibody (Product # PA5-30164) at a dilution of 1:500. Antigen Retrieval: Citrate buffer, pH 6.0, 15 min.

SERPINB3 Antibody in Western Blot, Immunocytochemistry (WB, ICC/IF)

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产品信息

PA5-30164

应用

建议稀释比

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免疫印迹 (WB)

1:500-1:3,000

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免疫组化 (IHC)

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免疫组化（石蜡） (IHC (P))

1:100-1:1,000

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免疫细胞化学 (ICC/IF)

1:100-1:1,000

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产品规格

种属反应

Human

已发表种属

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant fragment corresponding to a region within amino acids 89 and 359 of Human SerpinB3

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.57 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7, with 20% glycerol

内含物

0.025% ProClin 300

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

AB_2547638

产品详细信息

Recommended positive controls: H1299.

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

靶标信息

May act as a papain-like cysteine protease inhibitor to modulate the host immune response against tumor cells. Also functions as an inhibitor of UV-induced apoptosis via suppression of the activity of c-Jun NH(2)-terminal kinase (JNK1). [UniProt]

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

SerpinB3 drives cancer stem cell survival in glioblastoma.

Cell reports

Lauko A,Volovetz J,Turaga SM,Bayik D,Silver DJ,Mitchell K,Mulkearns-Hubert EE,Watson DC,Desai K,Midha M,Hao J,McCortney K,Steffens A,Naik U,Ahluwalia MS,Bao S,Horbinski C,Yu JS,Lathia JD

PA5-30164 was used in Immunohistochemistry to identify a GBM CSC-specific survival mechanism involving a cysteine protease inhibitor, SerpinB3, and provide a potential target to improve the efficacy of GBM therapies against therapeutically resistant CSCs.

Tue Sep 13 00:00:00 UTC 2022

SerpinB3 drives cancer stem cell survival in glioblastoma.

Cell reports

Lauko A,Volovetz J,Turaga SM,Bayik D,Silver DJ,Mitchell K,Mulkearns-Hubert EE,Watson DC,Desai K,Midha M,Hao J,McCortney K,Steffens A,Naik U,Ahluwalia MS,Bao S,Horbinski C,Yu JS,Lathia JD

Tue Sep 13 00:00:00 UTC 2022

SerpinB3 drives cancer stem cell survival in glioblastoma.

Cell reports

Lauko A,Volovetz J,Turaga SM,Bayik D,Silver DJ,Mitchell K,Mulkearns-Hubert EE,Watson DC,Desai K,Midha M,Hao J,McCortney K,Steffens A,Naik U,Ahluwalia MS,Bao S,Horbinski C,Yu JS,Lathia JD

Tue Sep 13 00:00:00 UTC 2022

Hepatocyte-Specific Deletion of HIF2α Prevents NASH-Related Liver Carcinogenesis by Decreasing Cancer Cell Proliferation.

Cellular and molecular gastroenterology and hepatology

Foglia B,Sutti S,Cannito S,Rosso C,Maggiora M,Autelli R,Novo E,Bocca C,Villano G,Ramavath NN,Younes R,Tusa I,Rovida E,Pontisso P,Bugianesi E,Albano E,Parola M

PA5-30164 was used immunohistochemistry (paraffin) investigate the involvement of hepatocyte HIF-2α in experimental nonalcoholic steatohepatitis (NASH)-related carcinogenesis.

Mon Apr 04 00:00:00 UTC 2022

生物信息学

蛋白别名: Protein T4-A; SCCA-1; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 3; Serpin B3; serpin peptidase inhibitor, clade B (ovalbumin), member 3; spb3; Squamous cell carcinoma antigen 1

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基因别名: HsT1196; SCC; SCCA; SCCA-1; SCCA-PD; SCCA1; SERPINB3; SSCA1; T4-A

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UniProt ID: (Human) P29508

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Entrez Gene ID: (Human) 6317

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功能

virus receptor activity protease binding serine-type endopeptidase inhibitor activity cysteine-type endopeptidase inhibitor activity protease inhibitor

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