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产品信息
H00008710-B01P
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
SERPINB7 (NP_003775.1, 1 a.a. approximately 380 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MASLAAANAE FCFNLFREMD DNQGNGNVFF SSLSLFAALA LVRLGAQDDS LSQIDKLLHV NTASGYGNSS NSQSGLQSQL KRVFSDINAS HKDYDLSIVN GLFAEKVYGF HKDYIECAEK LYDAKVERVD FTNHLEDTRR NINKWVENET HGKIKNVIGE GGISSSAVMV LVNAVYFKGK WQSAFTKSET INCHFKSPKC SGKAVAMMHQ ERKFNLSVIE DPSMKILELR YNGGINMYVL LPENDLSEIE NKLTFQNLME WTNPRRMTSK YVEVFFPQFK IEKNYEMKQY LRALGLKDIF DESKADLSGI ASGGRLYISR MMHKSYIEVT EEGTEATAAT GSNIVEKQLP QSTLFRADHP FLFVIRKDDI ILFSGKVSCP
靶标信息
Megsin, also designated SerpinB7 and TP55, is a 380 amino acid cytoplasmic protein that is predominantly expressed in mesangial cells, which play an important role in maintaining glomerular structure and function. As a member of the serpin family, megsin is a serine protesase inhibitor which potentially inactivate MMP-2, MMP-9 and plasmin, proteins that are notably responsible for degradation of extracellular matrix. Overexpression of megsin results in an increase in number of mesangial cells and therefore a progressive mesangial matrix expansion, which is accompanied by immune complex deposition. This finding suggests that megsin significantly influences the role of mesangial cells in renal structure and is likely implicated in a variety of nephropathies.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Megsin; mesangium predominant gene, megsin; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 7; Serpin B7; serpin peptidase inhibitor, clade B (ovalbumin), member 7; Serpin-B7; TP55
基因别名: MEGSIN; PPKN; SERPINB7; TP55
UniProt ID: (Human) O75635
Entrez Gene ID: (Human) 8710
