Invitrogen

SERPINB9 Polyclonal Antibody

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SERPINB9 Antibody (PA5-51038) in WB

Oncoimmunology 2022 - Figure 6. MUC1-C and PBRM1/PBAF drive ISG15 and SERPINB9 expression. (a). Expression of ISG15 and SERPINB9 in the TCGA-PRAD cohort was assessed in MUC1-high and MUC1-low groups using a Wilcoxon rank-sum test. (b). Lysates from DU-145/tet-MUC1shRNA treated with vehicle or DOX for 7 days were immunoblotted with antibodies against the indicated proteins. (c). Lysates from DU-145/CsgRNA or DU-145/MUC1sgRNA#1 we... View More

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产品信息

PA5-51038

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:2,000

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免疫组化 (IHC)

1:100-1:300

免疫组化（冰冻） (IHC (F))

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产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthesized peptide derived from the Internal region of human PI-9 (aa 241-290).

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.4, with 50% glycerol, 0.5% BSA

内含物

0.02% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

AB_2636486

产品详细信息

Serpin B9 Polyclonal Antibody detects endogenous levels of Serpin B9 protein.

靶标信息

PI9 belongs to the large superfamily of serine proteinase inhibitors (serpins), which bind to and inactivate serine proteinases. These interactions are involved in many cellular processes, including coagulation, fibrinolysis, complement fixation, matrix remodeling, and apoptosis (Sprecher et al., 1995 [PubMed 8530382]).

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

MUC1-C integrates type II interferon and chromatin remodeling pathways in immunosuppression of prostate cancer.

Oncoimmunology

Hagiwara M,Fushimi A,Bhattacharya A,Yamashita N,Morimoto Y,Oya M,Withers HG,Hu Q,Liu T,Liu S,Wong KK,Long MD,Kufe D

PA5-51038 was used in Western Blot to demonstrate that MUC1-C is necessary for expression of IFNGR1 and activation of the type II interferon-gamma (IFN-γ) pathway.

Fri Apr 08 00:00:00 UTC 2022

MUC1-C integrates type II interferon and chromatin remodeling pathways in immunosuppression of prostate cancer.

Oncoimmunology

Hagiwara M,Fushimi A,Bhattacharya A,Yamashita N,Morimoto Y,Oya M,Withers HG,Hu Q,Liu T,Liu S,Wong KK,Long MD,Kufe D

PA5-51038 was used in Western Blot to demonstrate that MUC1-C is necessary for expression of IFNGR1 and activation of the type II interferon-gamma (IFN-γ) pathway.

Fri Apr 08 00:00:00 UTC 2022

Direct Tumor Killing and Immunotherapy through Anti-SerpinB9 Therapy.

Cell

Jiang L,Wang YJ,Zhao J,Uehara M,Hou Q,Kasinath V,Ichimura T,Banouni N,Dai L,Li X,Greiner DL,Shultz LD,Zhang X,Sun ZJ,Curtin I,Vangos NE,Yeoh ZC,Geffken EA,Seo HS,Liu ZX,Heffron GJ,Shah K,Dhe-Paganon S,Abdi R

PA5-51038 was used in Western Blot, Immunohistochemistry (Frozen) to describe a molecular target that permits a combination of tumor ablation, interference within the TME, and immunotherapy in one potential modality.

Wed Nov 25 00:00:00 UTC 2020

Direct Tumor Killing and Immunotherapy through Anti-SerpinB9 Therapy.

Cell

Wed Nov 25 00:00:00 UTC 2020

生物信息学

蛋白别名: CAP-3; Cytoplasmic antiproteinase 3; Peptidase inhibitor 9; PI-9; protease inhibitor 9 (ovalbumin type); serine (or cysteine) peptidase inhibitor, clade B, member 9; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 9; serine (or cysteine) proteinase inhibitor, clade B, member 9; serine protease inhibitor 6; Serpin B9; serpin peptidase inhibitor, clade B (ovalbumin), member 9; serpin peptidase inhibitor, clade B, member 9; testicular tissue protein Li 180

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基因别名: BB283241; CAP-3; CAP3; ovalbumin; PI-9; PI9; SERPINB9; Spi6

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UniProt ID: (Human) P50453

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Entrez Gene ID: (Human) 5272, (Rat) 361241, (Mouse) 20723

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功能

protease binding serine-type endopeptidase inhibitor activity protein binding cysteine-type endopeptidase inhibitor activity involved in apoptotic process molecular_function protease inhibitor

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