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产品信息
PA5-17317
产品规格
种属反应
Human,
Mouse,
Non-human primate,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to the human SET7/SET9 protein
偶联物
形式
Liquid
纯化类型
Antigen affinity chromatography
保存液
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
内含物
no preservative
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_10982735
产品详细信息
It is not recommended to aliquot this antibody.
This antibody is not cross-reactive with other SET domain-containing proteins.
靶标信息
Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: FLJ21193; H3-K4 methyltransferase; H3-K4-HMTase; H3-K4-HMTase SETD7; Histone H3-K4 methyltransferase SETD7; histone H3-lysine 4-specific methyltransferase; Histone-lysine N-methyltransferase SETD7; Lysine N-methyltransferase 7; OTTHUMP00000220049; SET domain containing (lysine methyltransferase) 7; SET domain-containing protein 7; SET7/9
基因别名: 1600028F23Rik; H3K4MT; KIAA1717; KMT7; mKIAA1717; SET7; SET7/9; SET9; SETD7
UniProt ID: (Human) Q8WTS6, (Mouse) Q8VHL1
Entrez Gene ID: (Human) 80854, (Rat) 689954, (Mouse) 73251
transcription, DNA-templated
cellular response to DNA damage stimulus
chromatin modification
peptidyl-lysine monomethylation
peptidyl-lysine dimethylation
histone lysine methylation
response to ethanol
positive regulation of transcription, DNA-templated
regulation of histone H3-K9 methylation
heterochromatin organization
biological_process
peptidyl-lysine methylation
negative regulation of transferase activity
regulation of transcription, DNA-templated
methylation
