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SETD7 Chimeric Antibody (MA5-48338) in ICC/IF
Immunocytochemistry/Immunofluorescence analysis of SETD7 in HeLa cells using SETD7 Chimeric Monoclonal Antibody (Product # MA5-48338). Cells were fixed with paraformaldehyde, permeabilized with 0.15% Triton and stained with SETD7 Chimeric Monoclonal Antibody at a dilution of 1:100 for 1h followed by Alexa Fluor 488 secondary antibody (1:1,500 dilution), showing cytoplasmic staining. The nuclear stain is DAP... View More
产品信息
MA5-48338
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG, kappa
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
RAB-C220
抗原
This antibody was obtained by recombinant antibody (rAb) phage display recognizing SETD7 protein under non-denaturing conditions.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
0.02% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_3074780
产品详细信息
Specificity: This antibody recognizes SETD7 (Histone-lysine N-methyltransferase SETD7). It binds to a folded domain, amino acids 2-366. SETD7 is a histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. It plays a central role in the transcriptional activation of genes such as collagenase or insulin.
靶标信息
Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: FLJ21193; H3-K4-HMTase; H3-K4-HMTase SETD7; Histone H3-K4 methyltransferase SETD7; histone H3-lysine 4-specific methyltransferase; Histone-lysine N-methyltransferase SETD7; Lysine N-methyltransferase 7; OTTHUMP00000220049; SET domain containing (lysine methyltransferase) 7; SET domain-containing protein 7; SET7/9
基因别名: KIAA1717; KMT7; SET7; SET7/9; SET9; SETD7
UniProt ID: (Human) Q8WTS6
Entrez Gene ID: (Human) 80854
transcription, DNA-templated
cellular response to DNA damage stimulus
chromatin modification
peptidyl-lysine monomethylation
peptidyl-lysine dimethylation
histone lysine methylation
response to ethanol
positive regulation of transcription, DNA-templated
regulation of histone H3-K9 methylation
heterochromatin organization
