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产品信息
H00006419-B01P
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
SETMAR (AAH11635.1, 1 a.a. approximately 352 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MAEFKEKPEA PTEQLDVACG QENLPVGAWP PGAAPAPFQY TPDHVVGPGA DIDPTQITFP GCICVKTPCL PGTCSCLRHG ENYDDNSCLR DIGSGGKYAE PVFECNVLCR CSDHCRNRVV QKGLQFHFQV FKTHKKGWGL RTLEFIPKGR FVCEYAGEVL GFSEVQRRIH LQTKSDSNYI IAIREHVYNG QVMETFVDPT YIGNIGRFLN HSCEPNLLMI PVRIDSMVPK LALFAAKDIV PEEELSYDYS GRYLNLTVSE DKERLDHGKL RKPCYCGAKS CTAFLPFDSS LYCPVEKSNI SCGNEKEPSM CGSAPSVFPS CKRLTLEVSL FSDKQLAPPY SGRQWLASFT SA
靶标信息
SETMAR (SET domain and mariner transposase fusion gene) is a histone methyltransferase that methylates Lys-4 and Lys-36 of histone H3, creating specific tags for epigenetic transcriptional activation. It specifically mediates dimethylation of H3 Lys-36. SETMAR has sequence-specific DNA-binding activity, and recognizes the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 transposable element. SETMAT has DNA nicking activity, and in vivo end-joining activity, and may mediate genomic integration of foreign DNA.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Histone-lysine N-methyltransferase SETMAR; Metnase; SET domain and mariner transposase fusion gene-containing protein; SET domain and mariner transposase fusion protein
基因别名: Mar1; METNASE; SETMAR
UniProt ID: (Human) Q53H47
Entrez Gene ID: (Human) 6419
single-stranded DNA endodeoxyribonuclease activity
double-stranded DNA binding
single-stranded DNA binding
endonuclease activity
protein binding
zinc ion binding
histone methyltransferase activity (H3-K4 specific)
protein homodimerization activity
structure-specific DNA binding
DNA topoisomerase binding
histone methyltransferase activity (H3-K36 specific)
viral or transposable element protein
histone modifying enzyme
DNA double-strand break processing
DNA catabolic process, endonucleolytic
double-strand break repair via nonhomologous end joining
cell proliferation
histone H3-K36 methylation
DNA integration
replication fork processing
mitotic DNA integrity checkpoint
histone H3-K4 methylation
negative regulation of cell cycle arrest
nucleic acid phosphodiester bond hydrolysis
histone H3-K36 dimethylation
positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity
positive regulation of double-strand break repair via nonhomologous end joining
negative regulation of chromosome organization
