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产品信息
PA1-4138
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to residues A(25) P A R C E E Y D Y Y G W Q(38) of human SFRP5.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2187200
产品详细信息
PA1-4138 detects human SFRP5.
PA1-4138 has been successfully used in Western blot procedures. By Western blot this antibody detects a ~40 kDa protein representing human SFRP5 in pancreas lysate.
The PA1-4138 immunogen is a synthetic peptide corresponding to residues A(25) P A R C E E Y D Y Y G W Q(38) of human SFRP5. This sequence is 92% conserved in bovine, 82% conserved in rat, and 78% conserved in mouse.
Maintain at 4ºC for 3 months or at -20ºC for longer periods. Stable for 1 year. Avoid freeze/thaw cycles.
靶标信息
Secreted frizzled-related protein 5 (SFRP5) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. SFRP5 and SFRP1 may be involved in determining the polarity of photoreceptor cells in the retina. SFRP5 is highly expressed in the retinal pigment epithelium, and moderately expressed in the pancreas.
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生物信息学
蛋白别名: Frizzled-related protein 1b; FRP-1b; SARP-3; secreted apoptosis related protein 3; Secreted apoptosis-related protein 3; Secreted frizzled-related protein 5; sFRP-5
基因别名: FRP1B; SARP3; SFRP5
UniProt ID: (Human) Q5T4F7
Entrez Gene ID: (Human) 6425
apoptotic process
establishment or maintenance of cell polarity
signal transduction
G-protein coupled receptor signaling pathway
multicellular organism development
visual perception
negative regulation of cell proliferation
anatomical structure morphogenesis
cell differentiation
negative regulation of Wnt signaling pathway
negative regulation of catenin import into nucleus
non-canonical Wnt signaling pathway
negative regulation of sequence-specific DNA binding transcription factor activity
negative regulation of protein kinase B signaling
negative regulation of canonical Wnt signaling pathway
negative regulation of Wnt signaling pathway involved in digestive tract morphogenesis
