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产品信息
SFRP5-501AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide taken within amino acid region 150-200 on SFRP5
偶联物
形式
Liquid
浓度
0.5-1.5 mg/mL
纯化类型
Affinity chromatography
保存液
proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Secreted frizzled-related protein 5 (SFRP5) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. SFRP5 and SFRP1 may be involved in determining the polarity of photoreceptor cells in the retina. SFRP5 is highly expressed in the retinal pigment epithelium, and moderately expressed in the pancreas.
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生物信息学
蛋白别名: Frizzled-related protein 1b; FRP-1b; SARP-3; secreted apoptosis related protein 3; Secreted apoptosis-related protein 3; Secreted frizzled-related protein 5; secreted frizzled-related sequence protein 5; sFRP-5
基因别名: AI605071; FRP1B; SARP3; SFRP5
UniProt ID: (Human) Q5T4F7, (Mouse) Q9WU66
Entrez Gene ID: (Human) 6425, (Mouse) 54612, (Rat) 309377
apoptotic process
establishment or maintenance of cell polarity
signal transduction
G-protein coupled receptor signaling pathway
multicellular organism development
visual perception
negative regulation of cell proliferation
anatomical structure morphogenesis
cell differentiation
negative regulation of Wnt signaling pathway
negative regulation of catenin import into nucleus
non-canonical Wnt signaling pathway
negative regulation of sequence-specific DNA binding transcription factor activity
negative regulation of protein kinase B signaling
negative regulation of canonical Wnt signaling pathway
negative regulation of Wnt signaling pathway involved in digestive tract morphogenesis
Wnt signaling pathway
post-anal tail morphogenesis
negative regulation of JUN kinase activity
digestive tract morphogenesis
convergent extension involved in axis elongation
canonical Wnt signaling pathway
regulation of establishment of planar polarity
planar cell polarity pathway involved in neural tube closure
negative regulation of planar cell polarity pathway involved in axis elongation
biological_process
