Invitrogen

SFTPB Polyclonal Antibody

SFTPB Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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SFTPB Antibody (PA5-42000) in IHC (P)

Immunohistochemistry (paraffin-embedded) analysis of human lung tissue using an anti-Surfactant Protein B polyclonal antibody (Product # PA5-42000).; Secondary Antibody: Donkey anti-Rabbit-Cy3.

SFTPB Antibody in Immunohistochemistry (IHC)

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产品信息

PA5-42000

应用

建议稀释比

已发表文章

免疫印迹 (WB)

0.2-1 µg/mL

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免疫组化 (IHC)

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免疫组化（石蜡） (IHC (P))

1:200

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产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human, Mouse, Rhesus monkey

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide directed towards the middle region of human SFTPB

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Affinity Chromatography

保存液

PBS with 2% sucrose

内含物

0.09% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Wet ice

AB_2609628

产品详细信息

Peptide sequence: PGALQARPGP HTQDLSEQQF PIPLPYCWLC RALIKRIQAM IPKGALAVAV

Sequence homology: Cow: 86%; Dog: 100%; Guinea Pig: 100%; Human: 100%; Mouse: 92%; Rabbit: 85%; Rat: 100%; Sheep: 79%

靶标信息

Pulmonary surfactant is a complex mixture of phospholipids and proteins that is secreted from type II cells in alveoli and reduces the surface tension at the alveolar air-liquid interface, providing alveolar stability necessary for normal ventilation. Four distinct proteins isolated from pulmonary surfactant are termed surfactant proteins A, B, C, and D. SP-A (28-36kDa) and SP-D (43kDa) are collagenous carbohydrate-binding proteins, whereas SP-B (8-9kDa) and SP-C (4kDa) are non-collagenous hydrophobic proteins. SP-B is expressed in pulmonary adenocarcinomas with acinar, papillary, bronchioloalveolar, and solid growth patterns. Squamous cell and large cell carcinomas of the lung and nonpulmonary adenocarcinomas do not express SP-B. ProSP-B is glycosylated in the Golgi apparatus and undergoes carboxy- and amino-terminal proteolysis by a cathepsin D-like protease.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Sigmar1 ablation leads to lung pathological changes associated with pulmonary fibrosis, inflammation, and altered surfactant proteins levels.

Frontiers in physiology

Remex NS,Abdullah CS,Aishwarya R,Nitu SS,Traylor J,Hartman B,King J,Bhuiyan MAN,Kevil CG,Orr AW,Bhuiyan MS

PA5-42000 was used in Western Blotting to determine the expression of Sigmar1 in the lungs.

Thu May 16 00:00:00 UTC 2024

Human distal lung maps and lineage hierarchies reveal a bipotent progenitor.

Nature

Kadur Lakshminarasimha Murthy P,Sontake V,Tata A,Kobayashi Y,Macadlo L,Okuda K,Conchola AS,Nakano S,Gregory S,Miller LA,Spence JR,Engelhardt JF,Boucher RC,Rock JR,Randell SH,Tata PR

PA5-42000 was used in Immunohistochemistry (Paraffin), Western Blot to revise human lung cell maps and lineage trajectories, and implicate an epithelial transitional state in primate lung regeneration and disease.

Fri Apr 01 00:00:00 UTC 2022

Defined conditions for long-term expansion of murine and human alveolar epithelial stem cells in three-dimensional cultures.

STAR protocols

Konishi S,Tata A,Tata PR

PA5-42000 was used in Immunohistochemistry to describe a detailed protocol for the isolation, purification, and culture of murine and human AT2s.

Fri Jun 17 00:00:00 UTC 2022

Human Lung Stem Cell-Based Alveolospheres Provide Insights into SARS-CoV-2-Mediated Interferon Responses and Pneumocyte Dysfunction.

Cell stem cell

Katsura H,Sontake V,Tata A,Kobayashi Y,Edwards CE,Heaton BE,Konkimalla A,Asakura T,Mikami Y,Fritch EJ,Lee PJ,Heaton NS,Boucher RC,Randell SH,Baric RS,Tata PR

PA5-42000 was used in Immunohistochemistry to report a feeder-free, scalable, chemically defined, and modular alveolosphere culture system for the propagation and differentiation of human alveolar type 2 cells/pneumocytes derived from primary lung tissue.

Thu Dec 03 00:00:00 UTC 2020

Human Lung Stem Cell-Based Alveolospheres Provide Insights into SARS-CoV-2-Mediated Interferon Responses and Pneumocyte Dysfunction.

Cell stem cell

Katsura H,Sontake V,Tata A,Kobayashi Y,Edwards CE,Heaton BE,Konkimalla A,Asakura T,Mikami Y,Fritch EJ,Lee PJ,Heaton NS,Boucher RC,Randell SH,Baric RS,Tata PR

Thu Dec 03 00:00:00 UTC 2020

Human Lung Stem Cell-Based Alveolospheres Provide Insights into SARS-CoV-2-Mediated Interferon Responses and Pneumocyte Dysfunction.

Cell stem cell

Katsura H,Sontake V,Tata A,Kobayashi Y,Edwards CE,Heaton BE,Konkimalla A,Asakura T,Mikami Y,Fritch EJ,Lee PJ,Heaton NS,Boucher RC,Randell SH,Baric RS,Tata PR

Thu Dec 03 00:00:00 UTC 2020

生物信息学

蛋白别名: 18 kDa pulmonary-surfactant protein; 6 kDa protein; P SFTB3; Pulmonary surfactant-associated protein B; Pulmonary surfactant-associated proteolipid SPL(Phe); SFPB; SP-B; surfactant associated protein B; surfactant pulmonary-associated protein B; surfactant, pulmonary-associated protein B

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基因别名: AI562151; PSP-B; SF-B; SFTB3; Sftp-3; SFTP3; SFTPB; SMDP1; SP-B

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UniProt ID: (Human) P07988, (Rat) P22355, (Mouse) P50405

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Entrez Gene ID: (Human) 6439, (Rat) 192155, (Mouse) 20388

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功能

G-protein coupled receptor binding enzyme activator activity molecular_function scaffold/adaptor protein

参与通路