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产品信息
PA5-57673
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2647252
产品详细信息
Immunogen sequence: PPGVILPMMP AKHIPPARDS RRPEPKPDKS RLFQLKNDMG LECGHKVLAK EVKKPNLRPI SKSKTDLPEE KPDATPQNPF LKSRPQV
Highest antigen sequence identity to the following orthologs: Mouse - 78%, Rat - 80%.
靶标信息
Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Adapter protein HOFI; adaptor protein HOFI; Factor for adipocyte differentiation 49; FLJ20831; SH3 and PX domain-containing protein 2B; Tyrosine kinase substrate with four SH3 domains
基因别名: FAD49; FTHS; HOFI; KIAA1295; SH3PXD2B; TKS4; TSK4
UniProt ID: (Human) A1X283
Entrez Gene ID: (Human) 285590
skeletal system development
eye development
superoxide metabolic process
heart development
extracellular matrix disassembly
cell differentiation
positive regulation of catalytic activity
positive regulation of fat cell differentiation
oxidation-reduction process
bone development
adipose tissue development
podosome assembly
protein localization to membrane
