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SHANK2 Antibody (PA5-78652) in ICC/IF
SHANK2 Polyclonal Antibody detects SHANK2 protein at cell body and synaptic vesicles by immunofluorescent analysis. Sample: DIV9 rat E18 primary cortical neurons were fixed in 4% paraformaldehyde at RT for 15 min. Green: SHANK2 protein stained by SHANK2 Polyclonal Antibody (Product # PA5-78652) diluted at 1:500. Red: beta Tubulin 3/ Tuj1, a neuron cell marker, stained by beta-3 Tubulin Polyclonal Antibody [GT11710] diluted at 1:500. Blue: Fluoroshield with DAPI .
产品信息
PA5-78652
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse,
Rat
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein encompassing a sequence within the C-terminus region of mouse SHANK2. The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
0.23 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 20% glycerol, 1% BSA
内含物
0.025% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2736592
产品详细信息
Positive Control: mouse brain, rat brain
Predicted Reactivity: Human (86%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density of excitatory synapses. Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats, and an SH3 domain. This particular family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the postsynaptic densities of the adult and developing brain. Alterations in the encoded protein may be associated with susceptibility to autism spectrum disorder. Alternative splicing results in multiple transcript variants.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Cortactin-binding protein 1; CortBP1; CORTBP1CTTNBP1; GKAP/SAPAP-interacting protein; proline rich synapse associated protein 1; Proline-rich synapse-associated protein 1; ProSAP1; SH3 and multiple ankyrin repeat domains protein 2; SH3/ankyrin domain gene 2; Shank2; SPANK-3
基因别名: CortBP1; Kiaa1022; mKIAA1022; ProSAP1; Shank2; Spank-3
UniProt ID: (Mouse) Q80Z38, (Rat) Q9QX74
Entrez Gene ID: (Mouse) 210274, (Rat) 171093
