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SHMT1 Antibody (PA5-100183) in IHC (P)
Immunohistochemistry analysis of SHMT1 in human colorectal cancer. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with SHMT1 polyclonal antibody (Product # PA5-100183) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
产品信息
PA5-100183
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human SHMT1(Accession P34896), corresponding to amino acid residues V376-H426.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2815713
产品详细信息
Antibody detects endogenous levels of total SHMT1.
靶标信息
This gene encodes the cellular form of serine hydroxymethyltransferase, a pyridoxal phosphate-containing enzyme that catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. This reaction provides one carbon units for synthesis of methionine, thymidylate, and purines in the cytoplasm. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternative splicing of this gene results in 2 transcript variants encoding 2 different isoforms. Additional transcript variants have been described, but their biological validity has not been determined.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: cytoplasmic serine hydroxymethyltransferase; Glycine hydroxymethyltransferase; MGC15229; MGC24556; serine hydroxymethyltransferase 1 (soluble); Serine hydroxymethyltransferase, cytosolic; Serine methylase; SHMT
基因别名: AI324848; AI385541; C81125; CSHMT; LRRGT00032; mShmt; mshmt1; mshmt2; SHMT; SHMT1
UniProt ID: (Human) P34896, (Mouse) P50431
Entrez Gene ID: (Human) 6470, (Mouse) 20425, (Rat) 287379
glycine hydroxymethyltransferase activity
protein binding
L-allo-threonine aldolase activity
amino acid binding
pyridoxal phosphate binding
protein homodimerization activity
serine binding
catalytic activity
transferase activity
identical protein binding
methyltransferase
transferase
metabolite interconversion enzyme
dTMP biosynthetic process
glycine metabolic process
L-serine metabolic process
L-serine catabolic process
purine nucleobase biosynthetic process
glycine biosynthetic process from serine
tetrahydrofolate interconversion
carnitine biosynthetic process
tetrahydrofolate metabolic process
folic acid metabolic process
protein tetramerization
protein homotetramerization
cellular response to tetrahydrofolate
glycine biosynthetic process
one-carbon metabolic process
