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产品信息
PA5-27858
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein fragment corresponding to a region within amino acids 1 and 240 of Human SHMT1
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 1% BSA, 20% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2545334
产品详细信息
Recommended positive controls: U87-MG.
Predicted reactivity: Mouse (94%), Rat (95%), Zebrafish (83%), Xenopus laevis (84%), Rabbit (94%), Sheep (95%), Rhesus Monkey (99%), Chimpanzee (99%), Bovine (95%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
This gene encodes the cellular form of serine hydroxymethyltransferase, a pyridoxal phosphate-containing enzyme that catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. This reaction provides one carbon units for synthesis of methionine, thymidylate, and purines in the cytoplasm. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternative splicing of this gene results in 2 transcript variants encoding 2 different isoforms. Additional transcript variants have been described, but their biological validity has not been determined.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: cytoplasmic serine hydroxymethyltransferase; Glycine hydroxymethyltransferase; MGC15229; MGC24556; serine hydroxymethyltransferase 1 (soluble); Serine hydroxymethyltransferase, cytosolic; Serine methylase; SHMT
基因别名: CSHMT; SHMT; SHMT1
UniProt ID: (Human) P34896
Entrez Gene ID: (Human) 6470
dTMP biosynthetic process
glycine metabolic process
L-serine metabolic process
L-serine catabolic process
purine nucleobase biosynthetic process
glycine biosynthetic process from serine
tetrahydrofolate interconversion
carnitine biosynthetic process
tetrahydrofolate metabolic process
folic acid metabolic process
protein tetramerization
protein homotetramerization
cellular response to tetrahydrofolate
