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SIM1 and SIM2 genes are Drosophila single-minded (sim) gene homologs. SIM1 transcript was detected only in fetal kidney out of various adult and fetal tissues tested. Since the sim gene plays an important role in Drosophila development and has peak levels of expression during the period of neurogenesis, it was proposed that the human SIM gene is a candidate for involvement in certain dysmorphic features (particularly the facial and skull characteristics), abnormalities of brain development, and/or mental retardation of Down syndrome.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: bHLH-PAS transcription factor; single-minded family bHLH transcription factor 1a
基因别名: sim1
Entrez Gene ID: (Zebrafish) 260351