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产品信息
PA5-59853
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.4 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2647313
产品详细信息
Immunogen sequence: KGGSSDSGID TTLYTSSPSC MSLAKAPRPA KPHKPPGSMG LCGGGREAAG RSHHADRRRE VSPAPAVAGQ SKGYRPKLYS SG
Highest antigen sequence identity to the following orthologs: Mouse - 89%, Rat - 89%.
靶标信息
Signal-induced proliferation associated-like protein 2 (SIPA1L3) is a member of the SIPA1 family of RapGAPs. SIPA1L3 was cloned as a novel molecular component of tight junctions and adherens junctions, suggesting that may function to balance Rap1 by counteracting RapGEFs. Recent studies of SIPA indicate that its deregulation can cause myeloproliferative stem cell disorders in mice and increased metastases in human cancers. Other studies suggest SIPA1L1 may play important roles in embryo development and control of cell proliferation. Based on the amount of homology between SIPA family members, it is possible that SIPA1L3 plays other roles development and cell proliferation.
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生物信息学
蛋白别名: signal-induced proliferation-associated 1 like 3; Signal-induced proliferation-associated 1-like protein 3; SIPA1-like protein 3; SPA-1-like 3; SPA-1-like protein 3
基因别名: CTRCT45; KIAA0545; SIPA1L3; SPAL3; SPAR3
UniProt ID: (Human) O60292
Entrez Gene ID: (Human) 23094
