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产品信息
H00006506-M10
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
4G8
抗原
SLC1A2 (NP_004162, 160 a.a. approximately 239 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
See Label
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Sequence of this protein is as follows: DEVSSLDAFL DLIRNLFPEN LVQACFQQIQ TVTKKVLVAP PPDEEANATS AVVSLLNETV TEVPEETKMV IKKGLEFKDG
靶标信息
Excitatory amino acid transporter 2 (EAAT2) is a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis (ALS.) Alternatively spliced transcript variants of this gene have been identified.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Excitatory amino acid transporter 2; excitotoxic amino acid transporter 2; GLT1a; GLT1b; GLT1c; Glutamate/aspartate transporter II; OTTHUMP00000165209; OTTHUMP00000165210; Sodium-dependent glutamate/aspartate transporter 2; solute carrier family 1 (glial high affinity glutamate transporter), member 2; Solute carrier family 1 member 2
基因别名: EAAT2; GLT-1; GLT1; HBGT; SLC1A2
UniProt ID: (Human) P43004
Entrez Gene ID: (Human) 6506
amino acid transmembrane transport
ion transport
chemical synaptic transmission
visual behavior
response to wounding
multicellular organism aging
glutamate secretion
telencephalon development
adult behavior
cellular response to extracellular stimulus
multicellular organism growth
response to drug
response to amino acid
positive regulation of glucose import
L-glutamate import
D-aspartate import
L-glutamate transmembrane transport
