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产品信息
H00006583-M01
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
2D3
抗原
SLC22A4 (NP_003050, 43 a.a. approximately 141 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Sandwich ELISA (Recombinant protein).
Immunogen sequence: AGTPEHRCRV PDAANLSSAW RNNSVPLRLR DGREVPHSCS RYRLATIANF SALGLEPGRD VDLGQLEQES CLDGWEFSQD VYLSTVVTEW NLVCEDNWK
靶标信息
Carnitine (b-hydroxy-g-trimethylaminobutyrate) is a small, highly polar compound that aids in the b-oxidation of long-chain fatty acids. Organic cation/carnitine transporters (OCTN) assist in the elimination of cationic compounds, including xenobiotics, and transport carnitine for reabsorption in the kidney. Similar to organic cation transporters (OCT), OCTN proteins localize to the plasma membrane of epithelial cells. OCTN1 is expressed in kidney, trachea, bone marrow and fetal liver. OCTN2 is abundantly expressed in kidney, skeletal muscle, placenta and heart. OCTN3 is strongly expressed in testis and weakly expressed in kidney. The gene encoding human OCTN1 maps to chromosome 5 and the gene encoding human OCTN2 maps to chromosome 5q31. Mutations in the gene encoding OCTN2 leads to systemic carnitine deficiency (SCD), an autosomal recessive disorder characterized by cardiomyopathy, skeletal myopathy, lethargy, hypoglycemia and hyperammonemia.
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生物信息学
蛋白别名: Ergothioneine transporter; ET transporter; integral membrane transport protein; OCTN1; Organic cation/carnitine transporter 1; solute carrier family 22 (organic cation/ergothioneine transporter), member 4; solute carrier family 22 (organic cation/zwitterion transporter), member 4; Solute carrier family 22 member 4
基因别名: ETT; OCTN1; SLC22A4; UT2H
UniProt ID: (Human) Q9H015
Entrez Gene ID: (Human) 6583
nucleotide binding
protein binding
ATP binding
secondary active organic cation transmembrane transporter activity
carnitine transmembrane transporter activity
symporter activity
cation:cation antiporter activity
quaternary ammonium group transmembrane transporter activity
PDZ domain binding
secondary carrier transporter
