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产品信息
PA5-52574
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2647535
产品详细信息
Immunogen sequence: VLHLDEAKDH NSLNNLRETL LSEKPNLAQV ELELKERDVL SVFLPDVPET E
Highest antigen sequence identity to the following orthologs: Mouse - 60%, Rat - 56%.
靶标信息
The heteromeric transporter OST Alpha/OST Beta facilitates the transport of bile and other steroid solutes across the basolateral epithelial cell membrane of intestine, liver, testis, kidney and adrenal gland. OST Alpha/OST Beta expression is induced by bile acids through ligand-dependent transactivation of their genes by FXR (Farnesoid X-activated receptor). This genetic regulation suggests that in response to changes in intracellular bile acid levels, bile acids adjust the rate of their own efflux from enterocytes. OST Beta is a 128 amino acid single-pass transmembrane protein that requires OST Alpha to localize to the plasma membrane. Coexpression of OST Alpha and OST Beta is also required to convert the OST Alpha subunit to a mature glycosylated endoglycosidase H-resistant form, suggesting that co-expression facilitates trafficking of OST Alpha through the golgi apparatus. Though widely expressed, OST Beta is present at highest levels in ileum.
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生物信息学
蛋白别名: organic solute transporter beta subunit; Organic solute transporter subunit beta; OST-beta; Solute carrier family 51 subunit beta; solute carrier family 51, beta subunit
基因别名: OSTB; OSTBETA; SLC51B
UniProt ID: (Human) Q3SYF5
Entrez Gene ID: (Human) 123264
