Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
图: 1 / 2
SLC6A4 Antibody (H00006532-D01P) in WB
Western Blot analysis of SLC6A4 expression in transfected 293T cell line (H00006532-T01) by SLC6A4 MaxPab polyclonal antibody.
Lane 1: SLC6A4 transfected lysate(70.30 KDa).
Lane 2: Non-transfected lysate.
Lane 1: SLC6A4 transfected lysate(70.30 KDa).
Lane 2: Non-transfected lysate.
产品信息
H00006532-D01P
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
SLC6A4 (AAH69484.1, 1 a.a. approximately 630 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
See Label
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Sequence of this protein is as follows: METTPLNSQK QLSACEDGED CQENGVLQKV VPTPGDKVES GQISNGYSAV PSPGAGDDTR HSIPATTTTL VAELHQGERE TWGKKVDFLL SVIGYAVDLG NVWRFPYICY QNGGGAFLLP YTIMAIFGGI PLFYMELALG QYHRNGCISI WRKICPIFKG IGYAICIIAF YIASYYNTIM AWALYYLISS FTDQLPWTSC KNSWNTGNCT NYFSEDNITW TLHSTSPAEE FYTRHVLQIH RSKGLQDLGG ISWQLALCIM LIFTVIYFSI WKGVKTSGKV VWVTATFPYI ILSVLLVRGA TLPGAWRGVL FYLKPNWQKL LETGVWIDAA AQIFFSLGPG FGVLLAFASY NKFNNNCYQD ALVTSVVNCM TSFVSGFVIF TVLGYMAEMR NEDVSEVAKD AGPSLLFITY AEAIANMPAS TFFAIIFFLM LITLGLDSTF AGLEGVITAV LDEFPHVWAK RRERFVLAVV ITCFFGSLVT LTFGGAYVVK LLEEYATGPA VLTVALIEAV AVSWFYGITQ FCRDVKEMLG FSPGWFWRIC WVAISPLFLL FIICSFLMSP PQLRLFQYNY PYWSIILGYC IGTSSFICIP TYIAYRLIIT PGTFKERIIK SITPETPTEI PCGDIRLNAV
靶标信息
SERT is an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: 5 OCD1; 5-hydroxytryptamine (serotonin) transporter; 5HT transporter; 5HTT; HGNC:11050; Na+/Cl- dependent serotonin transporter; OTTHUMP00000163633; serotonin transporter 1; SERT; Sodium-dependent serotonin transporter; Sodium-dependent serotonin transporter (5HT transporter) (5HTT); solute carrier family 6 (neurotransmitter transporter), member 4; solute carrier family 6 (neurotransmitter transporter, serotonin), member 4; Solute carrier family 6 member 4
基因别名: 5-HTT; 5-HTTLPR; 5HTT; AI323329; hSERT; HTT; OCD1; SERT; SERT1; SLC6A4
UniProt ID: (Human) P31645, (Mouse) Q60857
Entrez Gene ID: (Human) 6532, (Mouse) 15567
serotonin:sodium symporter activity
protein binding
monoamine transmembrane transporter activity
serotonin transmembrane transporter activity
myosin binding
syntaxin-1 binding
Rab GTPase binding
cocaine binding
protein homodimerization activity
metal ion binding
nitric-oxide synthase binding
actin filament binding
neurotransmitter:sodium symporter activity
symporter activity
primary active transporter
response to hypoxia
serotonin transport
chemical synaptic transmission
response to nutrient
memory
circadian rhythm
response to toxic substance
positive regulation of gene expression
monoamine transport
thalamus development
negative regulation of cerebellar granule cell precursor proliferation
negative regulation of synaptic transmission, dopaminergic
response to estradiol
social behavior
vasoconstriction
response to drug
sperm ejaculation
negative regulation of neuron differentiation
positive regulation of cell cycle
negative regulation of organ growth
brain morphogenesis
protein oligomerization
protein homooligomerization
serotonin uptake
transmembrane transport
cellular response to retinoic acid
cellular response to cGMP
transport
neurotransmitter transport
organic cation transport
sodium ion transmembrane transport
cellular response to organic substance
ammonium transmembrane transport
