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SLC6A4 Antibody (MA5-49900) in IHC (P)
Immunohistochemistry analysis with a SLC6A4 monoclonal antibody (Product # MA5-49900) using a dilution of 1:100 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30 min at RT. Then primary antibody (1% BSA) was incu... View More
产品信息
MA5-49900
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
9G3
抗原
A synthesized peptide derived from human Serotonin transporter
偶联物
形式
Liquid
浓度
0.25 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C or -80°C if preferred
运输条件
Wet ice
RRID
AB_3092708
靶标信息
SERT is an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 5 OCD1; 5-hydroxytryptamine (serotonin) transporter; 5HT transporter; 5HTT; HGNC:11050; Na+/Cl- dependent serotonin transporter; OTTHUMP00000163633; serotonin transporter 1; SERT; Sodium-dependent serotonin transporter; solute carrier family 6 (neurotransmitter transporter), member 4; solute carrier family 6 (neurotransmitter transporter, serotonin), member 4; Solute carrier family 6 member 4
基因别名: 5-HTT; 5-HTTLPR; 5HTT; hSERT; HTT; OCD1; SERT; SERT1; SLC6A4
UniProt ID: (Human) P31645
Entrez Gene ID: (Human) 6532
serotonin:sodium symporter activity
protein binding
monoamine transmembrane transporter activity
serotonin transmembrane transporter activity
myosin binding
syntaxin-1 binding
Rab GTPase binding
cocaine binding
protein homodimerization activity
metal ion binding
nitric-oxide synthase binding
actin filament binding
primary active transporter
response to hypoxia
serotonin transport
chemical synaptic transmission
response to nutrient
memory
circadian rhythm
response to toxic substance
positive regulation of gene expression
monoamine transport
thalamus development
negative regulation of cerebellar granule cell precursor proliferation
negative regulation of synaptic transmission, dopaminergic
response to estradiol
social behavior
vasoconstriction
response to drug
sperm ejaculation
negative regulation of neuron differentiation
positive regulation of cell cycle
negative regulation of organ growth
brain morphogenesis
protein oligomerization
protein homooligomerization
serotonin uptake
transmembrane transport
cellular response to retinoic acid
cellular response to cGMP
