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SLIT2 Antibody (PA5-90404) in WB
Western blot analysis of SLIT2 in extracts of 293T cells. Samples were incubated with SLIT2 Polyclonal antibody (Product # PA5-90404) followed by HRP Goat Anti-Rabbit IgG (H+L) secondary antibody at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
产品信息
PA5-90404
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1330-1529 of human Slit2 (NP_0047781)
偶联物
形式
Liquid
浓度
0.72 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2806054
产品详细信息
Immunogen sequence: LPGCEPCHKK VCAHGTCQPS SQAGFTCECQ EGWMGPLCDQ RTNDPCLGNK CVHGTCLPIN AFSYSCKCLE GHGGVLCDEE EDLFNPCQAI KCKHGKCRLS GLGQPYCECS SGYTGDSCDR EISCRGERIR DYYQKQQGYA ACQTTKKVSR LECRGGCAGG QCCGPLRSKR RKYSFECTDG SSFVDEVEKV VKCGCTRCVS; Positive Samples: 293T
靶标信息
SLIT2 are ligands for Robo receptors and play a vital role for axonal migration/navigation during neural development. A number of cleavage products through alternate splicing are reported in the literature for SLIT2 proteins. The C-terminal cleavage proteins are more diffusible than the larger N-terminal protein that is more tightly cell associated. SLIT2 protein is expressed in tissues such as fetal lung, kidney, and adult spinal cord.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: downregulated during adipocyte differentiation-1; neurogenic extracellular slit protein; Slit homolog 2 protein; Slit-2
基因别名: Drad-1; E030015M03Rik; E130320P19Rik; mKIAA4141; SLIL3; Slit-2; SLIT2
UniProt ID: (Human) O94813, (Mouse) Q9R1B9
Entrez Gene ID: (Human) 9353, (Mouse) 20563
GTPase inhibitor activity
calcium ion binding
protein binding
heparin binding
identical protein binding
protein homodimerization activity
laminin-1 binding
proteoglycan binding
heparan sulfate proteoglycan binding
Roundabout binding
receptor binding
chemorepellent activity
immunoglobulin superfamily cell adhesion molecule
ureteric bud development
negative regulation of protein phosphorylation
cell migration involved in sprouting angiogenesis
negative regulation of leukocyte chemotaxis
axon guidance
motor neuron axon guidance
negative regulation of lamellipodium assembly
negative regulation of endothelial cell migration
negative regulation of smooth muscle cell migration
spinal cord development
chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration
chemorepulsion involved in postnatal olfactory bulb interneuron migration
corticospinal neuron axon guidance through spinal cord
negative regulation of cell growth
negative regulation of cell migration
negative regulation of actin filament polymerization
retinal ganglion cell axon guidance
response to nutrient levels
cellular response to hormone stimulus
negative regulation of GTPase activity
Roundabout signaling pathway
positive regulation of apoptotic process
negative regulation of vascular permeability
branching morphogenesis of an epithelial tube
axon extension involved in axon guidance
negative regulation of inflammatory response
positive regulation of axonogenesis
negative chemotaxis
induction of negative chemotaxis
negative regulation of small GTPase mediated signal transduction
response to cortisol
apoptotic process involved in luteolysis
negative regulation of chemokine-mediated signaling pathway
cellular response to heparin
negative regulation of smooth muscle cell chemotaxis
negative regulation of mononuclear cell migration
negative regulation of neutrophil chemotaxis
negative regulation of monocyte chemotaxis
negative regulation of retinal ganglion cell axon guidance
negative regulation of cellular response to growth factor stimulus
metanephros development
in utero embryonic development
chemotaxis
multicellular organism development
nervous system development
axonogenesis
negative regulation of cell proliferation
negative regulation of gene expression
single organismal cell-cell adhesion
olfactory bulb development
telencephalon cell migration
cell differentiation
negative regulation of axon extension
dorsal/ventral axon guidance
neuron projection morphogenesis
mammary gland duct morphogenesis
mammary duct terminal end bud growth
