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产品信息
MA5-15687
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
5H3
抗原
Purified recombinant fragment of human SMAD6 expressed in E. Coli.
偶联物
形式
Liquid
浓度
Conc. Not Determined
保存液
ascites
内含物
0.03% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_10981633
产品详细信息
MA5-15687 targets SMAD6 in indirect ELISA, WB applications and shows reactivity with Human samples.
The MA5-15687 immunogen is purified recombinant fragment of human SMAD6 expressed in E. Coli.
.
MA5-15687 detects SMAD6 which has a predicted molecular weight of approximately 53kDa.
靶标信息
SMAD6 (mothers against decapentaplegic homolog 6) is an antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit selectively BMP (bone morphogenetic proteins) signaling by competing with the co-SMAD SMAD4 for receptor-activated SMAD1. SMAD6 is an inhibitory SMAD (I-SMAD) or antagonistic SMAD.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: MAD homolog 6; Mothers against decapentaplegic homolog 6; mothers against decapentaplegic, drosophila, homolog of, 6; SMAD; SMAD 6; SMAD family member 6; SMAD SMAD; SMAD, mothers against DPP homolog 6
基因别名: AOVD2; HsT17432; MADH6; MADH7; SMAD6
UniProt ID: (Human) O43541
Entrez Gene ID: (Human) 4091
RNA polymerase II core promoter proximal region sequence-specific DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity
ubiquitin protein ligase binding
type I transforming growth factor beta receptor binding
identical protein binding
transcription regulatory region DNA binding
metal ion binding
co-SMAD binding
I-SMAD binding
R-SMAD binding
type I activin receptor binding
ureteric bud development
outflow tract septum morphogenesis
mitral valve morphogenesis
pulmonary valve morphogenesis
ventricular septum development
transcription, DNA-templated
immune response
transforming growth factor beta receptor signaling pathway
zygotic specification of dorsal/ventral axis
negative regulation of cell proliferation
negative regulation of SMAD protein complex assembly
negative regulation of ossification
BMP signaling pathway
negative regulation of transforming growth factor beta receptor signaling pathway
negative regulation of BMP signaling pathway
cell-substrate adhesion
response to laminar fluid shear stress
aorta development
negative regulation of apoptotic process
response to estrogen
fat cell differentiation
negative regulation of pathway-restricted SMAD protein phosphorylation
coronary vasculature development
