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SMARCA2 Antibody (MA5-46933) in ICC/IF
Immunofluorescent analysis of SMARCA2 in HeLa cells. Cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: SMARCA2 stained by SMARCA2 monoclonal antibody (Product # MA5-46933) diluted at 1:500. Red: alpha Tubulin, a cytoskeleton marker, stained by alpha Tubulin antibody [GT114] diluted at 1:1,000.
产品信息
MA5-46933
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
HL1115
抗原
Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human SMARCA2. The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2938005
产品详细信息
Store as concentrated solution.
Centrifuge briefly prior to opening vial.
靶标信息
SMARCA2 encodes a protein that is a member of the SWI/SNF family of proteins and is highly similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. Two transcript variants encoding different isoforms have been found for this gene, which contains a trinucleotide repeat (CAG) length polymorphism.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ATP-dependent helicase SMARCA2; BAF190B; BRG1-associated factor 190B; FLJ36757; global transcription activator homologous sequence; hBRM; MGC74511; Probable global transcription activator SNF2L2; Protein brahma homolog; SNF2-alpha; SNF2/SWI2-like protein 2; subunit of the SWI/SNF chromatin remodeling complex; sucrose nonfermenting 2-like protein 2; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a2; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2
基因别名: 2610209L14Rik; BAF190; BAF190B; brahma; BRM; hBRM; hSNF2a; NCBRS; SMARCA2; SNF2; SNF2A; SNF2alpha; SNF2L2; SNF2LA; Sth1p; SWI2
UniProt ID: (Human) P51531, (Mouse) Q6DIC0
Entrez Gene ID: (Human) 6595, (Mouse) 67155, (Rat) 361745
RNA polymerase II transcription coactivator activity
chromatin binding
transcription coactivator activity
helicase activity
protein binding
ATP binding
DNA-dependent ATPase activity
histone binding
transcription regulatory region DNA binding
nucleotide binding
DNA binding
hydrolase activity
hydrolase activity, acting on acid anhydrides
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
ATPase activity
DNA helicase
negative regulation of transcription from RNA polymerase II promoter
chromatin remodeling
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
spermatid development
nervous system development
negative regulation of cell proliferation
negative regulation of cell growth
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
chromatin organization
nucleosome assembly
transcription from RNA polymerase II promoter
aortic smooth muscle cell differentiation
biological_process
metabolic process
